On-the-Spot Detection and Speciation of Cannabinoids Using Organic Thin-Film Transistors

被引：34

作者：

Comeau, Zachary J. ^{[1
,2
]}

Boileau, Nicholas T. ^{[2
]}

Lee, Tiah ^{[4
]}

Melville, Owen A. ^{[2
]}

Rice, Nicole A. ^{[2
]}

Troung, Yen ^{[1
]}

Harris, Cory S. ^{[4
]}

Lessard, Benoit H. ^{[2
]}

Shuhendler, Adam J. ^{[1
,3
]}

机构：

[1] Univ Ottawa, Chem & Biomol Sci, Ottawa, ON K1N 6N5, Canada

[2] Univ Ottawa, Chem & Biol Engn, Ottawa, ON K1N 6N5, Canada

[3] Univ Ottawa, Inst Heart, Ottawa, ON K1Y 4W7, Canada

[4] Univ Ottawa, Biol, Ottawa, ON K1N 6N5, Canada

来源：

ACS SENSORS | 2019年 / 4卷 / 10期

基金：

加拿大自然科学与工程研究理事会;

关键词：

analytical methods; CBD; organic thin-film transistors; sensors; THC; PERFORMANCE LIQUID-CHROMATOGRAPHY; IDENTIFICATION; CANNABIDIOL; MARIJUANA; PHTHALOCYANINES; SEMICONDUCTORS; SENSORS; SAMPLES;

D O I：

10.1021/acssensors.9b01150

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Quality control is imperative for Cannabis since the primary cannabinoids, Delta(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD), elicit very different pharmacological effects. THC/CBD ratios are currently determined by techniques not readily accessible by consumers or dispensaries and which are impractical for use in the field by law-enforcement agencies. CuPc- and F-16-CuPc-based organic thin-film transistors have been combined with a cannabinoid-sensitive chromophore for the detection and differentiation of THC and CBD. The combined use of these well-characterized and inexpensive p- and n-type materials afforded the determination of the CBD/THC ratio from rapid plant extracts, with results indistinguishable from high-pressure liquid chromatography. Analysis of the prepyrolyzed sample accurately predicted postpyrolysis THC/CBD, which ultimately influences the psychotropic and medicinal effects of the specific plant. The devices were also capable of vapor-phase sensing, producing a unique electrical output for THC and CBD relative to other potentially interfering vaporized organic products. The analysis of complex medicinal plant extracts and vapors, normally reserved for advanced analytical infrastructure, can be achieved with ease, at low cost, and on the spot, using organic thin-film transistors.

引用

页码：2706 / +

页数：19

共 49 条

[1] The therapeutic effects of Cannabis and cannabinoids: An update from the National Academies of Sciences, Engineering and Medicine report [J].

Abrams, Donald I. .

EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2018, 49 :7-11

[2] Minor oxygenated cannabinoids from high potency Cannabis sativa L. [J].

Ahmed, Safwat A. ;

Ross, Samir A. ;

Slade, Desmond ;

Radwan, Mohamed M. ;

Khan, Ikhlas A. ;

ElSohly, Mahmoud A. .

PHYTOCHEMISTRY, 2015, 117 :194-199

[3] Identification and quantification of cannabinoids in Cannabis sativa L. plants by high performance liquid chromatography-mass spectrometry [J].

Aizpurua-Olaizola, Oier ;

Omar, Jone ;

Navarro, Patricia ;

Olivares, Maitane ;

Etxebarria, Nestor ;

Usobiaga, Aresatz .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2014, 406 (29) :7549-7560

[4]

[Anonymous], 1979, EISEI KAGAKU

[5] Detection of Δ9-Tetrahydrocannabinol in Exhaled Breath Collected from Cannabis Users [J].

Beck, Olof ;

Sandqvist, Soren ;

Dubbelboer, Ilse ;

Franck, Johan .

JOURNAL OF ANALYTICAL TOXICOLOGY, 2011, 35 (08) :541-544

[6] P and N type copper phthalocyanines as effective semiconductors in organic thin-film transistor based DNA biosensors at elevated temperatures [J].

Boileau, Nicholas T. ;

Melville, Owen A. ;

Mirka, Brendan ;

Cranston, Rosemary ;

Lessard, Benoit H. .

RSC ADVANCES, 2019, 9 (04) :2133-2142

[7] The influence of air and temperature on the performance of PBDB-T and P3HT in organic thin film transistors [J].

Brixi, Samantha ;

Melville, Owen A. ;

Boileau, Nicholas T. ;

Lessard, Benoit H. .

JOURNAL OF MATERIALS CHEMISTRY C, 2018, 6 (44) :11972-11979

[8] High-mobility solution-processed copper phthalocyanine-based organic field-effect transistors [J].

Chaure, Nandu B. ;

Cammidge, Andrew N. ;

Chambrier, Isabelle ;

Cook, Michael J. ;

Cain, Markys G. ;

Murphy, Craig E. ;

Pal, Chandana ;

Ray, Asim K. .

SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS, 2011, 12 (02)

[9] Evaluating the selectivity of colorimetric test (Fast Blue BB salt) for the cannabinoids identification in marijuana street samples by UV-Vis, TLC, ESI(+)FT-ICR MS and ESI(+)MS/MS [J].

dos Santos, Nayara A. ;

Souza, Lindamara M. ;

Domingos, Eloilson ;

Franca, Hildegardo S. ;

Lacerda, Valdemar, Jr. ;

Beatriz, Adilson ;

Vaz, Boniek G. ;

Rodrigues, Rayza R. T. ;

Carvalho, Veronica V. ;

Merlo, Bianca B. ;

Kuster, Ricardo M. ;

Romao, Wanderson .

FORENSIC CHEMISTRY, 2016, 1 :13-21

[10] Organic Thin-Film Transistor (OTFT)-Based Sensors [J].

Elkington, Daniel ;

Cooling, Nathan ;

Belcher, Warwick ;

Dastoor, Paul C. ;

Zhou, Xiaojing .

ELECTRONICS, 2014, 3 (02) :234-254

← 1 2 3 4 5 →