Poly(butylcyanoacrylate) nanoparticles for topical delivery of 5-fluorouracil

被引：62
作者：
Simeonova, M
Velichkova, R
Ivanova, G
Enchev, V
Abrahams, I
机构：
[1] Bulgarian Acad Sci, Inst Polymers, Lab Amphiphil & Nonionogen Polymers, BU-1113 Sofia, Bulgaria
[2] Bulgarian Acad Sci, Inst Organ Chem, BU-1113 Sofia, Bulgaria
[3] Univ London Queen Mary Coll, Dept Chem, Struct Chem Grp, London E1 4NS, England
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2003年 / 263卷 / 1-2期
关键词：
poly(butylcyanoacrylate) nanoparticlcs; 5-fluorourcil; 5-fluorouracil-loaded nanoparticles; drug carriers; NMR; X-ray diffraction;
D O I：
10.1016/S0378-5173(03)00373-9
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Poly(butylcyanoacrylate) nanoparticles (PBCN) as a drug carrier of 5-fluorouracil (5FU) intended for topical treatment of skin lesia were investigated. The presence of 5FU (as saline Solution, pH 10-11) in the polymerization medium affected the polymerization as well as the nanoparticle formation by influencing the initiation of the polymerization reaction. 5FU acted as all initiator in the anionic polymerization of n-butylcyanoacrylate monomer through its nucleophilic nitrogen centers. The results obtained by GPC, H-1 NMR, and X-ray diffraction allude to a possible mechanism of cytostatic immobilization in the polymer matrix, with evidence for both free and bound forms of the drug, (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码：133 / 140
页数：8
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