The effects of synbiotic supplementation on thyroid function and inflammation in hypothyroid patients: A randomized, double-blind, placebo-controlled trial

被引:39
作者
Talebi, Sepide [1 ,2 ,3 ]
Karimifar, Mozhgan [1 ]
Heidari, Zahra [4 ]
Mohammadi, Hamed [5 ]
Askari, Gholamreza [2 ,3 ]
机构
[1] Isfahan Univ Med Sci, Isfahan Endocrine & Metab Res Ctr, Esfahan, Iran
[2] Isfahan Univ Med Sci, Food Secur Res Ctr, Sch Nutr & Food Sci, Esfahan, Iran
[3] Isfahan Univ Med Sci, Dept Community Nutr, Sch Nutr & Food Sci, Esfahan, Iran
[4] Isfahan Univ Med Sci, Sch Hlth, Dept Biostat & Epidemiol, Esfahan, Iran
[5] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Student Res Comm, Esfahan, Iran
关键词
Synbiotic; Thyroid function; Inflammation; Hypothyroidism; RHEUMATOID-ARTHRITIS; OXIDATIVE STRESS; GLYCEMIC CONTROL; ASSOCIATION; PROBIOTICS; GUIDELINES; DISEASE; PILOT;
D O I
10.1016/j.ctim.2019.102234
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Background: There is a positive link between thyroid homeostasis and the composition of gut microbiota. A limited number of studies have suggested the efficacy of probiotic products on levothyroxine metabolism and thyroid hormone activity. Therefore, the purpose of this study was to investigate the effect of synbiotic supplementation on thyroid function, inflammation markers, and blood pressure in subjects with hypothyroidism. Methods: This study was conducted as a randomized, double-blind, placebo-controlled trial involving 60 patients with hypothyroidism. Participants were randomly recruited into two groups to receive either 500 mg/day of synbiotic (n = 30) or a placebo (n = 30) for 8 weeks. Results: Thyroid-stimulating hormone concentration, levothyroxine dose, and fatigue severity scale score were significantly decreased after the 8-week intervention in the synbiotic group (P < 0.05), while there were no significant differences seen in the placebo group. In addition, FT3 at the end of intervention was significantly higher (P = 0.001) in both groups, although these changes were not significant between the two groups (P = 0.259). Synbiotic supplements led to a significant elevation in serum CRP (P = 0.006), but this increase was not significant between groups (P = 0.699). Moreover, no statistical significance was observed within or between groups in terms of anti-thyroid peroxidase, systolic blood pressure and diastolic blood pressure (P > 0.05). Conclusion: Synbiotic supplementation among hypothyroid patients for 8 weeks may have beneficial effects on thyroid function. Further studies with larger sample size and longer duration are needed to confirm the current findings.
引用
收藏
页数:6
相关论文
共 37 条
[1]   2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum [J].
Alexander, Erik K. ;
Pearce, Elizabeth N. ;
Brent, Gregory A. ;
Brown, Rosalind S. ;
Chen, Herbert ;
Dosiou, Chrysoula ;
Grobman, William A. ;
Laurberg, Peter ;
Lazarus, John H. ;
Mandel, Susan J. ;
Peeters, Robin P. ;
Sullivan, Scott .
THYROID, 2017, 27 (03) :315-+
[2]  
[Anonymous], 2017, P WORKSH MOD SIM CYB
[3]   The Effect of Symbiotic Supplementation on Liver Enzymes, C-reactive Protein and Ultrasound Findings in Patients with Non-alcoholic Fatty Liver Disease: A Clinical Trial [J].
Asgharian, Atefe ;
Askari, Gholamreza ;
Esmailzade, Ahmad ;
Feizi, Awat ;
Mohammadi, Vida .
INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 2016, 7
[4]   Effect of multi-strain probiotics (multi-strain microbial cell preparation) on glycemic control and other diabetes-related outcomes in people with type 2 diabetes: a randomized controlled trial [J].
Firouzi, Somayyeh ;
Majid, Hazreen Abdul ;
Ismail, Amin ;
Kamaruddin, Nor Azmi ;
Barakatun-Nisak, Mohd-Yusof .
EUROPEAN JOURNAL OF NUTRITION, 2017, 56 (04) :1535-1550
[5]   Clinical Practice Guidelines for Hypothyroidism in Adults: Cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association [J].
Garber, Jeffrey R. ;
Cobin, Rhoda H. ;
Gharib, Hossein ;
Hennessey, James V. ;
Klein, Irwin ;
Mechanick, Jeffrey I. ;
Pessah-Pollack, Rachel ;
Singer, Peter A. ;
Woeber, Kenneth A. .
THYROID, 2012, 22 (12) :1200-1235
[6]   Effects of probiotic therapy on the activity and activation of mild rheumatoid arthritis - a pilot study [J].
Hatakka, K ;
Martio, J ;
Korpela, M ;
Herranen, M ;
Poussa, T ;
Laasanen, T ;
Saxelin, M ;
Vapaatalo, H ;
Moilanen, E ;
Korpela, R .
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 2003, 32 (04) :211-215
[7]  
Hussain Z, 2019, Anaesthesia, Pain & Intensive Care, P205
[8]  
IPAQ Research Committee, 2005, GUIDELINES DATA PROC
[9]   Microbial Population Changes and Their Relationship with Human Health and Disease [J].
Isabel Alvarez-Mercado, Ana ;
Navarro-Oliveros, Miguel ;
Robles-Sanchez, Candido ;
Plaza-Diaz, Julio ;
Jose Saez-Lara, Maria ;
Munoz-Quezada, Sergio ;
Fontana, Luis ;
Abadia-Molina, Francisco .
MICROORGANISMS, 2019, 7 (03)
[10]  
Kazemi A, 2019, CLIN NUTR EDINBURGH