WNTs in the vertebrate nervous system: From patterning to neuronal connectivity

被引：518

作者：

Ciani, L ^{[1
]}

Salinas, PC ^{[1
]}

机构：

[1] UCL, Dept Anat & Dev Biol, London WC1E 6BT, England

来源：

NATURE REVIEWS NEUROSCIENCE | 2005年 / 6卷 / 05期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1038/nrn1665

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WNT signalling has a key role in early embryonic patterning through the regulation of cell fate decisions, tissue polarity and cell movements. In the nervous system, WNT signalling also regulates neuronal connectivity by controlling axon pathfinding, axon remodelling, dendrite morphogenesis and synapse formation. Studies, from invertebrates to mammals, have led to a considerable understanding of WNT signal transduction pathways. This knowledge provides a framework for the study of the mechanisms by which WNTs regulate diverse neuronal functions. Manipulation of the WNT pathways could provide new strategies for nerve regeneration and neuronal circuit modulation.

引用

页码：351 / U17

页数：14

共 141 条

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