Spectral characterization, electrochemical, antimicrobial and cytotoxic studies on new metal (II) complexes containing N2O4 donor hexadentate Schiff base ligand

被引:23
|
作者
Alothman, Asma A. [1 ]
Al-Farraj, Eida S. [2 ]
Al-Onazi, Wedad A. [1 ]
Almarhoon, Zainab M. [1 ]
Al-Mohaimeed, Amal M. [1 ]
机构
[1] King Saud Univ, Coll Sci, Dept Chem, POB 22452, Riyadh 11495, Saudi Arabia
[2] Imam Mohammad Ibn Saud Islamic Univ IMSIU, Dept Chem, Coll Sci, Riyadh 11623, Saudi Arabia
关键词
Electrochemical; Schiff base metal(II) complexes; Antimicrobial screening; Cytotoxic activity; ZN(II) COMPLEXES; CU(II); CO(II); NI(II); DNA; ANTIOXIDANT; COPPER(II); ANTICANCER; BEHAVIOR; DESIGN;
D O I
10.1016/j.arabjc.2019.02.003
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We report the biological activity of the new Schiff base ligand H2L (H2L = 6,6'-((1E, 11E)-5,8-dioxa-2,11-diazadodeca- 1,11-diene-1,12-diyl)bis(2,4-dichlorophenol)), its derived metal(II) complexes [Cu(L)] (1), [Co(L)] (2), [Ni(L)] (3) and [Zn(L)] (4), along with their structural characterizations by using various analytical and spectroscopic techniques. Electrochemical investigations showed that all of these Cu(II), Co(II) and Ni(II) complexes were reversibly reducible. Although the change of the number of unpaired electrons are different of the metal cations, they have an effect on the redox potentials of the Co(II)/(I), Ni(II)/(I) and Cu(II)/(I) couples. The H-1 NMR and FTIR data concluded that the Schiff base ligand H2L acts as a hexadentate ligand co-ordinating with metal(II) ions through the oxygen atoms of the (-C-O-C), phenolic (-C-OH) groups and nitrogen atom of the azomethine (-CH=N-) group. UV-Visible absorption spectra studies clearly revealed the octahedral geometry of the prepared metal(II) complexes. Complexes 1 and 4 were found to be efficient in bringing about antimicrobial activities. The proposed mechanism of their antimicrobial activities has been discussed. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed the remarkable cytotoxicity of complex 1 (IC50 = 17 +/- 1.3 mu g/mL) on human breast cancer MCF-7 cells than Schiff base ligand H2L and complexes 2-4. Moreover, AO/EB staining assay revealed cell death due to apoptosis in MCF-7 cells and the generation of ROS by the Schiff base ligand H2L and its derived metal(II) complexes 1-4 may be a possible cause for their cytotoxic activity. (C) 2019 Production and hosting by Elsevier B.V. on behalf of King Saud University.
引用
收藏
页码:3889 / 3902
页数:14
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