Non-carboxylic analogues of naproxen: Design, synthesis, and pharmacological evaluation of some 1,3,4-oxadiazole/thiadiazole and 1,2,4-triazole derivatives

被引：49

作者：

Amir, Mohammad ^{[1
]}

Kumar, Harish ^{[1
]}

Javed, Sadique A. ^{[1
]}

机构：

[1] Hamdard Univ, Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India

来源：

ARCHIV DER PHARMAZIE | 2007年 / 340卷 / 11期

关键词：

anti-inflammatory; naproxen; 1,3,4-oxadiazoles; thiadiazoles; 1,2,4-triazoles;

D O I：

10.1002/ardp.200700065

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of substituted 1,3,4-oxadiazole (2-7 and 14-19), 1,2,4-triazole (20-25), and 1,3,4-thiadiazole (26-31) derivatives of naproxen have been synthesized by cyclization of 2-(6-methoxy-2naphthyl)propanoic acid hydrazide 1 and N-1[2-(6-methoxy-2-naphthyl) propanoyl]-N-4-alkyl/arylthiosemicarbazides (8-13) under various reaction conditions. All the compounds were screened for their anti-inflammatory activity by carrageenan-induced rat paw edema test method. Compounds showing high anti-inflammatory activity were also tested for their analgesic, ulcerogenic, and lipid peroxidation. Few of the synthesized compounds showed significant anti-inflammatory and analgesic activities along with reduced ulcerogenic effect and lipid peroxidation.

引用

页码：577 / 585

页数：9

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