Sterigmatocystins from the deep-sea-derived fungus Aspergillus versicolor

被引：40
|
作者：
Cai, Shengxin [1 ]
Zhu, Tianjiao [1 ]
Du, Lin [1 ]
Zhao, Boyu [1 ]
Li, Dehai [1 ]
Gu, Qianqun [1 ]
机构：
[1] Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Sch Med & Pharm, Qingdao 266003, Peoples R China
来源：
JOURNAL OF ANTIBIOTICS | 2011年 / 64卷 / 02期
关键词：
Aspergillus versicolor; deep-sea; fungus; sterigmatocystin; PHIALOCEPHALA SP FL30R; PENICILLIUM SP; ALKALOIDS; METABOLITES; XANTHONES; ASSAY;
D O I：
10.1038/ja.2010.154
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Three new sterigmatocystin derivatives, oxisterigmatocystin A (1), oxisterigmatocystin B (2) and oxisterigmatocystin C (3), together with one known compound, 5-methoxysterigmatocystin (4), were isolated from the deep-sea-derived fungus Aspergillus versicolor. The structures of the new compounds were elucidated by spectroscopic methods. The cytotoxicities of compounds 1-4 were evaluated against the A-549 and HL-60 cell lines. Compound 4 exhibited moderate cytotoxicities against the A-549 and HL-60 cell lines with IC(50) value of 3.86 and 5.32 mu m, respectively. The Journal of Antibiotics (2011) 64, 193-196; doi:10.1038/ja.2010.154; published online 1 December 2010
引用
收藏
页码：193 / 196
页数：4
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