The synthesis of isotopically labelled glucosinolates for analysis and metabolic studies

被引：7

作者：

Botting, Nigel P. ^{[1
]}

Robertson, Avril A. B. ^{[1
]}

Morrison, John J. ^{[1
]}

机构：

[1] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2007年 / 50卷 / 5-6期

关键词：

glucosinolates; isothiocyanates; glucoraphanin; sulforaphane; Brassicas;

D O I：

10.1002/jlcr.1225

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Glucosinolates are dietary natural products with important cancer chemoprevention proper-ties. The syntheses of a number of stable isotopically labelled ((2) H, C-13) glucosinolates, and their desulfo-analogues, are described. These compounds are used as internal standards for analysis and for metabolic studies. Copyright (c) 2007 John Wiley & Sons, Ltd.

引用

页码：260 / 263

页数：4

共 22 条

[1] A NEW MUSTARD OIL GLUCOSIDE SYNTHESIS - SYNTHESIS OF GLUCOTROPAEOLIN [J].

BENN, MH .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1963, 41 (11) :2836-&

[2] GLUCOSINOLATES AND THEIR BREAKDOWN PRODUCTS IN FOOD AND FOOD PLANTS [J].

FENWICK, GR ;

HEANEY, RK ;

MULLIN, WJ .

CRC CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 1983, 18 (02) :123-201

[3] Purification and characterisation of epithiospecifier protein from Brassica napus:: enzymic intramolecular sulphur addition within alkenyl thiohydroximates derived from alkenyl glucosinolate hydrolysis [J].

Foo, HL ;

Gronning, LM ;

Goodenough, L ;

Bones, AM ;

Danielsen, BE ;

Whiting, DA ;

Rossiter, JT .

FEBS LETTERS, 2000, 468 (2-3) :243-246

[4]

Griffiths DW, 2000, PHYTOCHEM ANALYSIS, V11, P216, DOI 10.1002/1099-1565(200007/08)11:4&lt

[5]

216::AID-PCA526&gt

[6]

3.0.CO

[7]

2-2

[8] Formation of glucoraphanin by chemoselective oxidation of natural glucoerucin: A chemoenzymatic route to sulforaphane [J].

Iori, R ;

Bernardi, R ;

Gueyrard, D ;

Rollin, P ;

Polmieri, S .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (07) :1047-1048

[9]

ISHIDA M, 1997, AGR RES Q, V131, P73

[10] Glucosinolate chemistry. First synthesis of glucosinolates bearing an external thio-function [J].

Mavratzotis, M ;

Dourtoglou, V ;

Lorin, C ;

Rollin, P .

TETRAHEDRON LETTERS, 1996, 37 (32) :5699-5700

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