The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X

被引：44

作者：

Bentley, DR

Deloukas, P

Dunham, A

French, L

Gregory, SG

Humphray, SJ

Mungall, AJ

Ross, MT

Carter, NP

Dunham, I

Scott, CE

Ashcroft, KJ

Atkinson, AL

Aubin, K

Beare, DM

Bethel, G

Brady, N

Brook, JC

Burford, DC

Burrill, WD

Burrows, C

Butler, AP

Carder, C

Catanese, JJ

Clee, CM

Clegg, SM

Cobley, V

Coffey, AJ

Cole, CG

Collins, JE

Conquer, JS

Cooper, RA

Culley, KM

Dawson, E

Dearden, FL

Durbin, RM

de Jong, PJ

Dhami, PD

Earthrowl, ME

Edwards, CA

Evans, RS

Gillson, CJ

Ghori, J

Green, L

Gwilliam, R

Halls, KS

Hammond, S

Harper, GL

Heathcott, RW

Holden, JL

机构：

[1] Sanger Ctr, Cambridge CB10 1SA, England

[2] Univ Crete, Dept Biol, CY-71409 Iraklion, Crete, Greece

[3] Inst Mol Biol & Biotechnol, CY-71409 Iraklion, Crete, Greece

[4] Cyprus Inst Neurol & Genet, Neurogenet Lab, CY-1683 Nicosia, Cyprus

[5] Childrens Hosp, BACPAC Resources, Oakland, CA 94609 USA

来源：

NATURE | 2001年 / 409卷 / 6822期

关键词：

D O I：

10.1038/35057165

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We constructed maps for eight chromosomes (1, 6, 9, 10, 13, 20, X and (previously) 22), representing one-third of the genome, by building landmark maps, isolating bacterial clones and assembling contigs. By this approach, we could establish the long-range organization of the maps early in the project, and all contig extension, gap closure and problem-solving was simplified by containment within local regions. The maps currently represent more than 94% of the euchromatic (gene-containing) regions of these chromosomes in 176 contigs, and contain 96% of the chromosome-specific markers in the human gene map. By measuring the remaining gaps, we can assess chromosome length and coverage in sequenced clones.

引用

页码：942 / 943

页数：2

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