Natural autoantibodies as tools to predict the outcome of immune response?

被引：47
作者：
Kohler, H
Bayry, J
Nicoletti, A
Kaveri, SV
机构：
[1] Univ Kentucky, Lucille P Markey Canc Ctr, Dept Microbiol & Immunol, Lexington, KY 40536 USA
[2] Univ Paris 06, Inst Cordeliers, Paris, France
[3] INSERM, U430, Paris, France
来源：
SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2003年 / 58卷 / 03期
关键词：
D O I：
10.1046/j.1365-3083.2003.01314.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Natural autoantibodies (NAbs), produced by B-1 B-cells, are directed against autoantigens and pathogens. NAbs can capture and present antigen to T helper cells thereby initiating adaptive immunities. It is proposed that screening for NAbs against pathogens will predict the strength of an antigen-induced immune response and could be used as a tool for vaccine development.
引用
收藏
页码：285 / 289
页数：5
相关论文
共 36 条
[1]   THE NATURAL AUTOANTIBODIES SYSTEM - BETWEEN HYPOTHESES AND FACTS [J].
AVRAMEAS, S ;
TERNYNCK, T .
MOLECULAR IMMUNOLOGY, 1993, 30 (12) :1133-1142
[2]  
AVRAMEAS S, 1991, IMMUNOL TODAY, V12, P154
[3]   B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection [J].
Baumgarth, N ;
Herman, OC ;
Jager, GC ;
Brown, LE ;
Herzenberg, LA ;
Chen, JZ .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (02) :271-280
[4]   Origins and functions of B-1 cells with notes on the role of CD5 [J].
Berland, R ;
Wortis, HH .
ANNUAL REVIEW OF IMMUNOLOGY, 2002, 20 :253-300
[5]  
Boes M, 1998, J IMMUNOL, V160, P4776
[6]  
Bondada S, 2000, CURR TOP MICROBIOL, V252, P141
[7]   Antibodies to C-C chemokine receptor 5 in normal human IgG block infection of macrophages and lymphocytes with primary R5-tropic strains of HIV-1 [J].
Bouhlal, H ;
Hocini, H ;
Quillent-Grégoire, C ;
Donkova, V ;
Rose, S ;
Amara, A ;
Longhi, R ;
Haeffner-Cavaillon, N ;
Beretta, A ;
Kaveri, SV ;
Kazatchkine, MD .
JOURNAL OF IMMUNOLOGY, 2001, 166 (12) :7606-7611
[8]   ANTI-PHOSPHOCHOLINE ANTIBODIES FOUND IN NORMAL MOUSE SERUM ARE PROTECTIVE AGAINST INTRAVENOUS INFECTION WITH TYPE-3 STREPTOCOCCUS-PNEUMONIAE [J].
BRILES, DE ;
NAHM, M ;
SCHROER, K ;
DAVIE, J ;
BAKER, P ;
KEARNEY, J ;
BARLETTA, R .
JOURNAL OF EXPERIMENTAL MEDICINE, 1981, 153 (03) :694-705
[9]   THE EFFECTS OF IDIOTYPE ON THE ABILITY OF IGG1 ANTI-PHOSPHORYLCHOLINE ANTIBODIES TO PROTECT MICE FROM FATAL INFECTION WITH STREPTOCOCCUS-PNEUMONIAE [J].
BRILES, DE ;
FORMAN, C ;
HUDAK, S ;
CLAFLIN, JL .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1984, 14 (11) :1027-1030
[10]  
Carroll MC, 1998, CURR OPIN IMMUNOL, V10, P36
1234