Association Between Immune-Related Adverse Events During Anti-PD-1 Therapy and Tumor Mutational Burden

被引:105
作者
Bomze, David [1 ]
Ali, Omar Hasan [2 ]
Bate, Andrew [3 ]
Flatz, Lukas [1 ]
机构
[1] Kantonsspital St Gallen, Inst Immunobiol, Rorschacher Str 95, CH-9007 St Gallen, Switzerland
[2] Univ Hosp Zurich, Dept Dermatol, Zurich, Switzerland
[3] NYU, Sch Med, Dept Med, Div Translat Med, New York, NY USA
基金
瑞士国家科学基金会;
关键词
D O I
10.1001/jamaoncol.2019.3221
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:1633 / 1635
页数:3
相关论文
共 6 条
[1]   Quantitative signal detection using spontaneous ADR reporting [J].
Bate, A. ;
Evans, S. J. W. .
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2009, 18 (06) :427-436
[2]   Exploiting the Mutanome for Tumor Vaccination [J].
Castle, John C. ;
Kreiter, Sebastian ;
Diekmann, Jan ;
Loewer, Martin ;
Van de Roemer, Niels ;
de Graaf, Jos ;
Selmi, Abderraouf ;
Diken, Mustafa ;
Boegel, Sebastian ;
Paret, Claudia ;
Koslowski, Michael ;
Kuhn, Andreas N. ;
Britten, Cedrik M. ;
Huber, Christoph ;
Tuereci, Oezlem ;
Sahin, Ugur .
CANCER RESEARCH, 2012, 72 (05) :1081-1091
[3]   Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden [J].
Chalmers, Zachary R. ;
Connelly, Caitlin F. ;
Fabrizio, David ;
Gay, Laurie ;
Ali, Siraj M. ;
Ennis, Riley ;
Schrock, Alexa ;
Campbell, Brittany ;
Shlien, Adam ;
Chmielecki, Juliann ;
Huang, Franklin ;
He, Yuting ;
Sun, James ;
Tabori, Uri ;
Kennedy, Mark ;
Lieber, Daniel S. ;
Roels, Steven ;
White, Jared ;
Otto, Geoffrey A. ;
Ross, Jeffrey S. ;
Garraway, Levi ;
Miller, Vincent A. ;
Stephens, Phillip J. ;
Frampton, Garrett M. .
GENOME MEDICINE, 2017, 9
[4]   Comprehensive Genomic Profiling of Hodgkin Lymphoma Reveals Recurrently Mutated Genes and Increased Mutation Burden [J].
Liang, Winnie S. ;
Vergilio, Jo-Anne ;
Salhia, Bodour ;
Huang, Helen J. ;
Oki, Yasuhiro ;
Garrido-Laguna, Ignacio ;
Park, Haeseong ;
Westin, Jason R. ;
Meric-Bernstam, Funda ;
Fabrizio, David ;
Miller, Vincent A. ;
Stephens, Philip J. ;
Fanale, Michelle A. ;
Ross, Jeffrey S. ;
Janku, Filip .
ONCOLOGIST, 2019, 24 (02) :219-228
[5]   Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance [J].
Martins, Filipe ;
Sofiya, Latifyan ;
Sykiotis, Gerasimos P. ;
Lamine, Faiza ;
Maillard, Michel ;
Fraga, Montserrat ;
Shabafrouz, Keyvan ;
Ribi, Camillo ;
Cairoli, Anne ;
Guex-Crosier, Yan ;
Kuntzer, Thierry ;
Michielin, Olivier ;
Peters, Solange ;
Coukos, Georges ;
Spertini, Francois ;
Thompson, John A. ;
Obeid, Michel .
NATURE REVIEWS CLINICAL ONCOLOGY, 2019, 16 (09) :563-580
[6]   Tumor Mutational Burden and Response Rate to PD-1 Inhibition [J].
Yarchoan, Mark ;
Hopkins, Alexander ;
Jaffee, Elizabeth M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (25) :2500-2501