Cytotoxic constituents of the octocoral Dendronephthya gigantea

被引：19

作者：

Han, AR

Song, JI

Jang, DS

Min, HY

Lee, SK

Seo, EK ^{[1
]}

机构：

[1] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea

[2] Ewha Womans Univ, Coll Nat Sci, Seoul 120750, South Korea

[3] Korea Inst Oriental Med, Dept Herbal Pharmaceut Dev, Taejon 305811, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2005年 / 28卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

soft coral; Dendronephthya gigantea; (+/-)-1-nonadecyloxy-2,3-propanediol; (2S,3R,4W,8E)-N-hexadecanoyl-2-amino-4,8-octadecadiene-1,3-diol; thymine; uracil; cytotoxicity;

D O I：

10.1007/BF02977794

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A known monoalkyl glycerol ether, (+/-)-1-nonadecyloxy-2,3-propanediol (1) was isolated from the ethyl acetate extract of a soft coral Dendronephthya gigantea as a weakly cytotoxic constituent against four human cancer cell lines, A549, HT-29, HT-1080, and SNU-638. In addition, a known ceramide, (2S,3R,4E,8E)-N-hexadecanoyl-2-amino-4,8-octadecadiene-1,3-diol (2), was also isolated as an inactive constituent. This is the first report on the isolation of the compounds 1 and 2 from the octocoral, Dendronephthya species.

引用

页码：290 / 293

页数：4

共 16 条

[1] A distinctive epibiotic bacterial community on the soft coral Dendronephthya sp and antibacterial activity of coral tissue extracts suggest a chemical mechanism against bacterial epibiosis [J].