Digital Twins for Bioprocess Control Strategy Development and Realisation

被引：16

作者：

Appl, Christian ^{[1
,2
]}

Moser, Andre ^{[1
]}

Baganz, Frank ^{[2
]}

Hass, Volker C. ^{[1
,2
]}

机构：

[1] Furtwangen Univ, Fac Med & Life Sci, Villingen Schwenningen, Germany

[2] UCL, Dept Biochem Engn, London, England

来源：

DIGITAL TWINS: APPLICATIONS TO THE DESIGN AND OPTIMIZATION OF BIOPROCESSES | 2021年 / 177卷

关键词：

Bioprocess; Control strategy development; Digital Twin; Operator training simulator (OTS); OPERATOR TRAINING SIMULATOR; FED-BATCH CULTIVATION; MODEL-BASED CONTROL; CELLS;

D O I：

10.1007/10_2020_151

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New innovative Digital Twins can represent complex bioprocesses, including the biological, physico-chemical, and chemical reaction kinetics, as well as the mechanical and physical characteristics of the reactors and the involved peripherals. Digital Twins are an ideal tool for the rapid and cost-effective development, realisation and optimisation of control and automation strategies. They may be utilised for the development and implementation of conventional controllers (e.g. temperature, dissolved oxygen, etc.), as well as for advanced control strategies (e.g. control of substrate or metabolite concentrations, multivariable controls), and the development of complete bioprocess control. This chapter describes the requirements Digital Twins must fulfil to be used for bioprocess control strategy development, and implementation and gives an overview of research projects where Digital Twins or "early-stage" Digital Twins were used in this context. Furthermore, applications of Digital Twins for the academic education of future control and bioprocess engineers as well as for the training of future bioreactor operators will be described. Finally, a case study is presented, in which an "early-stage" Digital Twin was applied for the development of control strategies of the fed-batch cultivation of Saccharomyces cerevisiae. [GRAPHICS] .

引用

页码：63 / 94

页数：32

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