Ligand-Controlled Regiodivergent Palladium-Catalyzed Decarboxylative Allylation Reaction to Access α,α-Difluoroketones

被引：76

作者：

Yang, Ming-Hsiu ^{[1
]}

Orsi, Douglas L. ^{[1
]}

Altman, Ryan A. ^{[1
]}

机构：

[1] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 08期

基金：

美国国家科学基金会;

关键词：

allylation; fluorine; palladium; phosphine ligands; regioselectivity; MIYAURA COUPLING PROCESSES; ALLYLIC ALKYLATION; ALPHA-FLUOROKETONES; INNER-SPHERE; REGIO; AMINATION; KETONES; ESTERS; TRIFLUOROMETHYLATION; FLUOROALKYLATION;

D O I：

10.1002/anie.201410039

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

alpha,alpha-Difluoroketones possess unique physicochemical properties that are useful for developing therapeutics and probes for chemical biology. To access the -allyl-,-difluoroketone substructure, complementary palladium-catalyzed decarboxylative allylation reactions were developed to provide linear and branched -allyl-,-difluoroketones. For these orthogonal processes, the fluorination pattern of the substrate enabled the ligands to dictate the regioselectivity of the transformations.

引用

页码：2361 / 2365

页数：5

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