Expressive language development of children exposed to cocaine prenatally: Literature review and report of a prospective cohort study

被引:49
作者
Delaney-Black, V
Covington, C
Templin, T
Kershaw, T
Nordstrom-Klee, B
Ager, J
Clark, N
Surendran, A
Martier, S
Sokol, RJ
机构
[1] Wayne State Univ, Sch Med, Dept Pediat, Detroit, MI 48201 USA
[2] Wayne State Univ, Coll Nursing, Detroit, MI 48202 USA
[3] Wayne State Univ, Sch Med, Dept Pediat, Detroit, MI 48201 USA
[4] Wayne State Univ, Sch Med, Ctr Healthcare Effectiveness Res, Detroit, MI USA
[5] Wayne State Univ, Sch Med, Dept Pediat, Detroit, MI 48201 USA
[6] Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USA
关键词
cocaine exposure; language development; teratogens;
D O I
10.1016/S0021-9924(00)00033-2
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
It was hypothesized that prenatal exposure to cocaine and other substances would be related to delayed expressive language development. Speech and language data were available for 458 6-year olds (204 were exposed to cocaine). No significant univariate or multivariate differences by cocaine exposure group were observed. Classification and regression tree modeling was then used to identify language variable composites predictive of cocaine exposure status. Meaningful cut points for two language measures were identified and validated. Children with a type token ratio of less than 0.42 and with fewer than 97 word types were classified into a low language group. Low language children (n = 57) were more likely to be cocaine exposed (63.1%), with cocaine-exposed children 2.4 times more likely to be in the low language group compared with control children after adjustment for covariates. Prenatal cigarette, but not alcohol exposure, was also significantly related to expressive language delays. (C) 2000 by Elsevier Science Inc.
引用
收藏
页码:463 / 481
页数:19
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