Priorities for future research into asthma diagnostic tools: A PAN-EU consensus exercise from the European asthma research innovation partnership (EARIP)

被引：27

作者：

Garcia-Marcos, L. ^{[1
,2
,3
]}

Edwards, J. ^{[4
]}

Kennington, E. ^{[4
]}

Aurora, P. ^{[5
,6
,7
]}

Baraldi, E. ^{[8
]}

Carraro, S. ^{[8
]}

Gappa, M. ^{[9
,10
]}

Louis, R. ^{[11
]}

Moreno-Galdo, A. ^{[12
]}

Peroni, D. G. ^{[13
]}

Pijnenburg, M. ^{[14
]}

Priftis, K. N. ^{[15
]}

Sanchez-Solis, M. ^{[1
,2
,3
]}

Schuster, A. ^{[16
]}

Walker, S. ^{[4
]}

机构：

[1] Univ Murcia, Arrixaca Univ Childrens Hosp, Resp Unit, Murcia, Spain

[2] Univ Murcia, Arrixaca Univ Childrens Hosp, Allergy Unit, Murcia, Spain

[3] IMIB Res Inst, Murcia, Spain

[4] Asthma UK, London, England

[5] Great Ormond St Hosp Sick Children, Dept Paediat Resp Med, London, England

[6] UCL, Dept Resp Crit Care, Great Ormond St Inst Child Hlth, London, England

[7] UCL, Anaesthesia Unit, Great Ormond St Inst Child Hlth, London, England

[8] Univ Padua, Womens & Childrens Hlth Dept, Padua, Italy

[9] Marienhosp Wesel, Childrens Hosp, Wesel, Germany

[10] Marienhosp Wesel, Res Inst, Wesel, Germany

[11] Univ Liege, Dept Resp Med, Liege, Belgium

[12] Univ Autonoma Barcelona, Paediat Pulmonol Unit, Hosp Vall dHebron, Barcelona, Spain

[13] Univ Pisa, Dept Clin & Expt Med, Paediat Sect, Pisa, Italy

[14] Erasmus MC Sophia Childrens Hosp, Paediat Paediat Resp Med, Rotterdam, Netherlands

[15] Univ Athens, Sch Med, Dept Paediat, Attikon Gen Hosp, Athens, Greece

[16] Univ Hosp, Dept Paediat, Dusseldorf, Germany

来源：

CLINICAL AND EXPERIMENTAL ALLERGY | 2018年 / 48卷 / 02期

关键词：

EXHALED BREATH CONDENSATE; EOSINOPHIL CATIONIC PROTEIN; VOLATILE ORGANIC-COMPOUNDS; AIR-FLOW OBSTRUCTION; INFANT LUNG-FUNCTION; EQUAL-TO; 12-PERCENT; NITRIC-OXIDE LEVELS; VENTILATION HETEROGENEITY; BRONCHODILATOR RESPONSE; CHILDHOOD ASTHMA;

D O I：

10.1111/cea.13080

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The diagnosis of asthma is currently based on clinical history, physical examination and lung function, and to date, there are no accurate objective tests either to confirm the diagnosis or to discriminate between different types of asthma. This consensus exercise reviews the state of the art in asthma diagnosis to identify opportunities for future investment based on the likelihood of their successful development, potential for widespread adoption and their perceived impact on asthma patients. Using a two-stage e-Delphi process and a summarizing workshop, a group of European asthma experts including health professionals, researchers, people with asthma and industry representatives ranked the potential impact of research investment in each technique or tool for asthma diagnosis and monitoring. After a systematic review of the literature, 21 statements were extracted and were subject of the two-stage Delphi process. Eleven statements were scored 3 or more and were further discussed and ranked in a face-to-face workshop. The three most important diagnostic/predictive tools ranked were as follows: New biological markers of asthma (eg genomics, proteomics and metabolomics) as a tool for diagnosis and/or monitoring, Prediction of future asthma in preschool children with reasonable accuracy and Tools to measure volatile organic compounds (VOCs) in exhaled breath.

引用

页码：104 / 120

页数：17

共 184 条

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