Dewerin and gilbertionol two new secondary metabolites from the stem bark ofGilbertiodendron dewevrei(De Wild) J. Leonard

The phytochemical investigation of the methanol extract of the stem bark ofGilbertiodendron dewevreiled to the isolation of two new secondary metabolites, 5,7-dihydroxy-4 '-methoxyisoflavan-2,4-dione (1) and 23-hydroxy-2-tricosanone (2) along with 19 known compounds (3-21). The structure of these compounds were established by interpretation of their spectral data, mainly HR-TOFESIMS, 1 D NMR (H-1,C-13 and DEPT) and 2 D NMR (H-1-H-1 COSY, HSQC, HMBC, and NOESY), and by comparison with those reported in the literature. The methanol extract and some isolates were screened for their antiradical, antibacterial, and inhibitory properties against acetylcholinesterase.