Treatment of advanced soft tissue sarcoma by histological subtype: wish, prediction or reality?

被引:6
作者
Blay, Jean-Yves [1 ]
机构
[1] Univ Claude Bernard, Ctr Leon Berard, Dept Med Oncol, Lyon, France
关键词
advanced soft tissue sarcoma; histological subtypes; targeted therapy; treatment sequence; PHASE-II; TRABECTEDIN; CHEMOTHERAPY; FAILURE; SAFETY;
D O I
10.2217/fon-2019-0488
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Soft tissue sarcomas (STS) are heterogenous cancers encompassing more than 100 histological and molecular subtypes. Their extreme rarity underscores the need for international collaboration to identify specific treatment protocols. Increasing knowledge of STS complexity as defined by molecular biology has led to the introduction of targeted therapies for several sarcoma subtypes, which is an encouraging start. In advanced STS, doxorubicin-based regimens are standard first-line chemotherapy. Options for second and later lines include ifosfamide, trabectedin, pazopanib, eribulin and gemcitabine-based regimens. Histological subtype has become a key factor when selecting best options to treat advanced sarcoma; however, the challenges of identifying optimal treatments for all STS histotypes are undeniably formidable. Fortunately, the sarcoma community shares the common goal of seeking greater knowledge about the characteristics of each subtype in order to improve diagnosis and outcomes. Progress made to date in this regard suggests that the vision to treat by subtype is achievable.
引用
收藏
页码:5 / 10
页数:6
相关论文
共 23 条
[1]  
[Anonymous], 2018, CANC CHEMOTHERAPY RE
[2]   Long-term outcome and effect of maintenance therapy in patients with advanced sarcoma treated with trabectedin: an analysis of 181 patients of the French ATU compassionate use program [J].
Blay, Jean-Yves ;
Italiano, Antoine ;
Ray-Coquard, Isabelle ;
Le Cesne, Axel ;
Duffaud, Florence ;
Rios, Maria ;
Collard, Olivier ;
Bertucci, Francois ;
Bompas, Emmanuelle ;
Isambert, Nicolas ;
Chaigneau, Loic ;
Cassier, Philippe ;
Bui, Binh ;
Decanter, Gauthier ;
Derbel, Olfa ;
Coindre, Jean-Michel ;
Zintl, Patrick ;
Badri, Nadia ;
Penel, Nicolas .
BMC CANCER, 2013, 13
[3]   Advanced soft-tissue sarcoma: a disease that is potentially curable for a subset of patients treated with chemotherapy [J].
Blay, JY ;
van Glabbeke, M ;
Verweij, J ;
van Oosterom, AT ;
Le Cesne, A ;
Oosterhuis, JW ;
Judson, I ;
Nielsen, OS .
EUROPEAN JOURNAL OF CANCER, 2003, 39 (01) :64-69
[4]   Crizotinib in ALK-Rearranged Inflammatory Myofibroblastic Tumor [J].
Butrynski, James E. ;
D'Adamo, David R. ;
Hornick, Jason L. ;
Dal Cin, Paola ;
Antonescu, Cristina R. ;
Jhanwar, Suresh C. ;
Ladanyi, Marc ;
Capelletti, Marzia ;
Rodig, Scott J. ;
Ramaiya, Nikhil ;
Kwak, Eunice L. ;
Clark, Jeffrey W. ;
Wilner, Keith D. ;
Christensen, James G. ;
Jaenne, Pasi A. ;
Maki, Robert G. ;
Demetri, George D. ;
Shapiro, Geoffrey I. .
NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (18) :1727-1733
[5]   Soft tissue and visceral sarcomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up (vol 29, pg 51, 2018) [J].
Casali, P. G. ;
Abecassis, N. ;
Aro, H. T. ;
Bauer, S. ;
Biagini, R. ;
Bielack, S. ;
Bonvalot, S. ;
Boukovinas, I. ;
Bovee, J. V. M. G. ;
Brodovvicz, T. ;
Broto, J. M. ;
Buonadonna, A. ;
De Alava, E. ;
Tos, A. P. Dei ;
Del Muro, X. G. ;
Dileo, P. ;
Eriksson, M. ;
Fedenko, A. ;
Ferraresi, V. ;
Ferrari, A. ;
Ferrari, S. ;
Frezza, A. M. ;
Gasperoni, S. ;
Gelderblom, H. ;
Gil, T. ;
Grignani, G. ;
Gronchi, A. ;
Haas, R. L. ;
Hassan, B. ;
Hohenberger, P. ;
Lssels, R. ;
Joensuu, H. ;
Jones, R. L. ;
Judson, I. ;
Jutte, P. ;
Kaal, S. ;
Kasper, B. ;
Kopeckova, K. ;
Krakorova, D. A. ;
Le Cesne, A. ;
Lugowska, I. ;
Merimsky, O. ;
Montemurro, M. ;
Pantaleo, M. A. ;
Piana, R. ;
Picci, P. ;
Piperno-Neumann, S. ;
Pousa, A. L. ;
Reichardt, P. ;
Robinson, M. H. .
ANNALS OF ONCOLOGY, 2018, 29 :268-269
[6]   Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial [J].
Demetri, George D. ;
von Mehren, Margaret ;
Jones, Robin L. ;
Hensley, Martee L. ;
Schuetze, Scott M. ;
Staddon, Arthur ;
Milhem, Mohammed ;
Elias, Anthony ;
Ganjoo, Kristen ;
Tawbi, Hussein ;
Van Tine, Brian A. ;
Spira, Alexander ;
Dean, Andrew ;
Khokhar, Nushmia Z. ;
Park, Youn Choi ;
Knoblauch, Roland E. ;
Parekh, Trilok V. ;
Maki, Robert G. ;
Patel, Shreyaskumar R. .
JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (08) :786-+
[7]   Incidence of Sarcoma Histotypes and Molecular Subtypes in a Prospective Epidemiological Study with Central Pathology Review and Molecular Testing [J].
Ducimetiere, Francoise ;
Lurkin, Antoine ;
Ranchere-Vince, Dominique ;
Decouvelaere, Anne-Valerie ;
Peoc'h, Michel ;
Istier, Luc ;
Chalabreysse, Philippe ;
Muller, Christine ;
Alberti, Laurent ;
Bringuier, Pierre-Paul ;
Scoazec, Jean-Yves ;
Schott, Anne-Marie ;
Bergeron, Christophe ;
Cellier, Dominic ;
Blay, Jean-Yves ;
Ray-Coquard, Isabelle .
PLOS ONE, 2011, 6 (08)
[8]   Phase II clinical trial of neoadjuvant trabectedin in patients with advanced localized myxoid liposarcoma [J].
Gronchi, A. ;
Bui, B. N. ;
Bonvalot, S. ;
Pilotti, S. ;
Ferrari, S. ;
Hohenberger, P. ;
Hohl, R. J. ;
Demetri, G. D. ;
Le Cesne, A. ;
Lardelli, P. ;
Perez, I. ;
Nieto, A. ;
Tercero, J. C. ;
Alfaro, V. ;
Tamborini, E. ;
Blay, J. Y. .
ANNALS OF ONCOLOGY, 2012, 23 (03) :771-776
[9]   Histotype-tailored neoadjuvant chemotherapy versus standard chemotherapy in patients with high-risk soft-tissue sarcomas (ISG-STS 1001): an international, open-label, randomised, controlled, phase 3, multicentre trial [J].
Gronchi, Alessandro ;
Ferrari, Stefano ;
Quagliuolo, Vittorio ;
Martin-Broto, J. ;
Lopez Pousa, Antonio ;
Grignani, Giovanni ;
Basso, Umberto ;
Blay, Jean-Yves ;
Tendero, Oscar ;
Diaz Beveridge, Robert ;
Ferraresi, Virginia ;
Lugowska, Iwona ;
Merlo, Domenico Franco ;
Fontana, Valeria ;
Marchesi, Emanuela ;
Donati, Davide Maria ;
Palassini, Elena ;
Palmerini, Emanuela ;
De Sanctis, Rita ;
Morosi, Carlo ;
Stacchiotti, Silvia ;
Bague, Silvia ;
Coindre, Jean Michelle ;
Dei Tos, Angelo Paolo ;
Picci, Piero ;
Bruzzi, Paolo ;
Casali, Paolo Giovanni .
LANCET ONCOLOGY, 2017, 18 (06) :812-822
[10]   Trabectedin in patients with advanced soft tissue sarcoma: A retrospective national analysis of the French Sarcoma Group [J].
Le Cesne, Axel ;
Ray-Coquard, Isabelle ;
Duffaud, Florence ;
Chevreau, Christine ;
Penel, Nicolas ;
Binh Bui Nguyen ;
Piperno-Neumann, Sophie ;
Delcambre, Corinne ;
Rios, Maria ;
Chaigneau, Loic ;
Le Maignan, Christine ;
Guillemet, Cecile ;
Bertucci, Francois ;
Bompas, Emmanuelle ;
Linassier, Claude ;
Olivier, Thimotee ;
Kurtz, Jean-Emmanuel ;
Even, Caroline ;
Cousin, Philippe ;
Blay, Jean Yves .
EUROPEAN JOURNAL OF CANCER, 2015, 51 (06) :742-750