Increasing the Efficacy of Bioorthogonal Click Reactions for Bioconjugation: A Comparative Study

被引：333
|
作者：
Besanceney-Webler, Christen [1 ]
Jiang, Hao [1 ]
Zheng, Tianqing [1 ]
Feng, Lei [1 ]
del Amo, David Soriano [1 ]
Wang, Wei [1 ]
Klivansky, Liana M. [2 ]
Marlow, Florence L. [1 ]
Liu, Yi [2 ]
Wu, Peng [1 ]
机构：
[1] Yeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA
[2] Univ Calif Berkeley, Lawrence Berkeley Lab, Mol Foundry, Berkeley, CA 94720 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 35期
基金：
美国国家卫生研究院;
关键词：
alkynes; azides; bioconjugation; bioorthogonal reactions; click chemistry; AZIDE-ALKYNE CYCLOADDITION; IN-VIVO; COPPER-FREE; CHEMISTRY; GLYCANS; CELLS;
D O I：
10.1002/anie.201101817
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Raising the bar: The efficacy of bioorthogonal reactions for bioconjugation has been thoroughly evaluated in four different biological settings. Powered by the development of new biocompatible ligands, the copper-catalyzed azide-alkyne cycloaddition (see picture) has brought about unsurpassed bioconjugation efficiency, and thus it holds great promise as a highly potent and adaptive tool for a broader spectrum of biological applications. © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：8051 / 8056
页数：6
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