Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease

被引：135
作者：
Rockenstein, E
Hansen, LA
Mallory, M
Trojanowski, JQ
Galasko, D
Masliah, E [1 ]
机构：
[1] Univ Calif San Diego, Dept Neurosci, Sch Med, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Pathol, Sch Med, La Jolla, CA 92093 USA
[3] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[4] Univ Penn, Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA
来源：
BRAIN RESEARCH | 2001年 / 914卷 / 1-2期
关键词：
Alzheimer's disease; Lewy body; neurodegeneration; Parkinson's disease; synuclein;
D O I：
10.1016/S0006-8993(01)02772-X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The main objective of this study was to determine if levels of alpha-, beta- and/or gamma -synuclein mRNAs are differentially affected in brains of Lewy body disease (LBD) and Alzheimer's disease (AD) patients, compared to controls. In control cases, highest levels of expression were observed in the neocortex and the lowest in basal ganglia and substantia nigra. beta -Synuclein was the most abundant message (75-80%), followed by gamma -synuclein (10-15%) and alpha -synuclein (8-10%). Analysis of the superior temporal cortex, a region selectively affected in LBD and AD, showed that compared to controls, levels of a-synuclein were increased in cases of diffuse LBD (DLBD), levels of beta -synuclein were decreased in AD and DLBD, and levels of gamma -synuclein were increased in AD cases. This study suggests that a critical balance among products of the synuclein gene is important to maintain normal brain function and that alterations in this balance might be associated with neurodegenerative disorders. (C) 2001 Elsevier Science BY All rights reserved.
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收藏
页码：48 / 56
页数：9
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