Regulatory T-cells in systemic lupus erythematosus and rheumatoid arthritis

被引：97
作者：
Chavele, Konstantia-Maria [1 ]
Ehrenstein, Michael R. [1 ]
机构：
[1] UCL, Ctr Rheumatol, London WC1E 6JF, England
来源：
FEBS LETTERS | 2011年 / 585卷 / 23期
关键词：
Regulatory T-cells (Tregs); Autoimmunity; SLE; RA; COLLAGEN-INDUCED ARTHRITIS; ANTIGEN-INDUCED ARTHRITIS; GROWTH-FACTOR-BETA; TNF-ALPHA THERAPY; PERIPHERAL-BLOOD; DENDRITIC CELLS; MEDIATED SUPPRESSION; FOXP3; EXPRESSION; SYNOVIAL-FLUID; SELF-TOLERANCE;
D O I：
10.1016/j.febslet.2011.07.043
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Regulatory T-cells (Tregs) are the guardians of peripheral tolerance acting to prevent autoimmune diseases such as systemic lupus erythomatosus (SLE) and rheumatoid arthritis ( RA). Defects in Tregs have been reported in these two diseases despite significant differences in their clinical phenotype and pathogenesis. In both diseases the potency of Treg fails to keep pace with the activation of effector cells and are unable to resist the ensuing inflammation. This review will discuss the phenotypic, numeric, and functional abnormalities in Tregs and their role in patients and murine models of SLE and RA. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：3603 / 3610
页数：8
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