MicroRNAs-Based Nano-Strategies as New Therapeutic Approach in Multiple Myeloma to Overcome Disease Progression and Drug Resistance

被引：45

作者：

Desantis, Vanessa ^{[1
]}

Saltarella, Ilaria ^{[1
]}

Lamanuzzi, Aurelia ^{[1
]}

Melaccio, Assunta ^{[1
]}

Solimando, Antonio Giovanni ^{[1
,2
]}

Mariggio, Maria Addolorata ^{[3
]}

Racanelli, Vito ^{[1
]}

Paradiso, Angelo ^{[2
]}

Vacca, Angelo ^{[1
]}

Frassanito, Maria Antonia ^{[3
]}

机构：

[1] Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, Unit Internal Med & Clin Oncol, I-70124 Bari, Italy

[2] IRCS Ist Tumori Giovanni Paolo II Bari, Expt Med Oncol, I-70124 Bari, Italy

[3] Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, Unit Gen Pathol, I-70124 Bari, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 09期

关键词：

microRNAs; exosomes; lipid-based nanocarriers; polymer-based nanocarriers; multiple myeloma; TUMOR-SUPPRESSOR; GENE DELIVERY; MEDIATED DELIVERY; CO-DELIVERY; STEM-CELLS; TGF-BETA; IN-VITRO; PHASE-I; CANCER; NANOPARTICLES;

D O I：

10.3390/ijms21093084

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs, or miRs) are single-strand short non-coding RNAs with a pivotal role in the regulation of physiological- or disease-associated cellular processes. They bind to target miRs modulating gene expression at post-transcriptional levels. Here, we present an overview of miRs deregulation in the pathogenesis of multiple myeloma (MM), and discuss the potential use of miRs/nanocarriers association in clinic. Since miRs can act as oncogenes or tumor suppressors, strategies based on their inhibition and/or replacement represent the new opportunities in cancer therapy. The miRs delivery systems include liposomes, polymers, and exosomes that increase their physical stability and prevent nuclease degradation. Phase I/II clinical trials support the importance of miRs as an innovative therapeutic approach in nanomedicine to prevent cancer progression and drug resistance. Results in clinical practice are promising.

引用

页数：17

共 126 条

[1] MicroRNA theragnostics for the clinical management of multiple myeloma [J].