Treatment Complications and Long-term Outcomes of Total Body Irradiation in Patients with Acute Lymphoblastic Leukemia: A Single Institute Experience

被引:26
|
作者
De Felice, Francesca [1 ]
Grapulin, Lavinia [1 ]
Musio, Daniela [1 ]
Pomponi, Jenny [1 ]
Di Felice, Cinzia [2 ]
Iori, Anna Paola [3 ]
Bertaina, Alice [4 ]
Tombolini, Vincenzo [1 ,5 ]
机构
[1] Univ Roma La Sapienza, Policlin Umberto I, Thrombosis Ctr, Dept Radiotherapy, Viale Regina Elena 326, I-00161 Rome, Italy
[2] Univ Roma La Sapienza, Policlin Umberto I, Thrombosis Ctr, Dept Med Phys, Rome, Italy
[3] Univ Roma La Sapienza, Policlin Umberto I, Thrombosis Ctr, Dept Cellular Biotechnol & Hematol, Rome, Italy
[4] IRCCS Bambino Gesu Childrens Hosp, Dept Pediat Hematol & Oncol, Rome, Italy
[5] Spencer Lorillard Fdn, Rome, Italy
关键词
Total body irradiation; hematologic cancer; acute lymphoblastic leukemia; child; conditioning regimen; radiotherapy; BONE-MARROW-TRANSPLANTATION; CHRONIC MYELOID-LEUKEMIA; RANDOMIZED-TRIAL; CONDITIONING REGIMENS; PREPARATIVE REGIMEN; CHILDHOOD-CANCER; BUSULFAN-CYTOXAN; 1ST REMISSION; CYCLOPHOSPHAMIDE; ADOLESCENTS;
D O I
10.21873/anticanres.11049
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: The aim of this study was to evaluate treatment-related toxicity and clinical outcomes of total body irradiation (TBI) in patients with acute lymphoblastic leukemia (ALL). Patients and Methods: We performed a retrospective review of all patients with ALL who underwent TBI-based conditioning regimen at our Institution between 2000 and 2012. Results: A total of 211 patients were included. The median follow-up was 40 months. The 5-year overall survival and disease-free survival were 64.7% and 62.8%, respectively. The 5-year overall survival rate for the 163 children was 67.6% (95% confidence interval=55-77%). Disease status at time of transplant did not improve disease-free survival. Gastrointestinal acute toxicity was the most common early side-effect (19.9%). Acute graft-versus-host disease was reported in 31 patients (14.7%). Main late toxicities were cataract induction (12.8%) and growth, gonadal and endocrine effects (36%). Conclusion: TBI-based conditioning regimen led to a high survival rate with remarkably low radiation-related toxicity, suggesting that TBI provides a feasible therapeutic option in patients with ALL.
引用
收藏
页码:4859 / 4864
页数:6
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