Regional Homogeneity of Resting-State Brain Abnormalities in Violent Juvenile Offenders: A Biomarker of Brain Immaturity?

被引：17

作者：

Chen, Chen ^{[1
,2
,3
,4
]}

Zhou, Jiansong ^{[1
,3
,4
]}

Liu, Chunhong ^{[5
,6
]}

Witt, Katrina ^{[7
]}

Zhang, Yingdong ^{[1
,3
,4
]}

Jing, Bin ^{[5
,6
]}

Li, Chun ^{[1
,3
,4
]}

Wang, Xiaoping ^{[1
,3
,4
]}

Li, Lingjiang ^{[1
,3
,4
]}

机构：

[1] Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China

[2] Minist Justice, Inst Forens Sci, Shanghai Key Lab Forens Med, Shanghai, Peoples R China

[3] Hunan Prov Technol Inst Psychiat, Changsha, Hunan, Peoples R China

[4] Key Lab Psychiat & Mental Hlth Hunan Prov, Changsha, Hunan, Peoples R China

[5] Capital Med Univ, Beijing Anding Hosp, Dept Radiol, Beijing, Peoples R China

[6] Capital Med Univ, Sch Biomed Engn, Beijing, Peoples R China

[7] Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford, England

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2015年 / 27卷 / 01期

基金：

中国国家自然科学基金;

关键词：

FRONTAL-LOBE DYSFUNCTION; K-SADS-PL; FUNCTIONAL CONNECTIVITY; ADOLESCENT BOYS; BEHAVIOR; CORTEX; DISORDERS; AGGRESSION; PREVALENCE; PREDICTION;

D O I：

10.1176/appi.neuropsych.13030044

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors investigated whether male violent juvenile offenders demonstrate any differences in local functional connectivity indicative of delayed maturation of the brain that may serve as a biomarker of violence. Twenty-nine violent juvenile offenders and 28 age-matched controls were recruited. Regional homogeneity (ReHo) method was used to analyze resting-state magnetic resonance images. Violent offenders showed significantly lower ReHo values in the right caudate, right medial prefrontal cortex, and left precuneus, and higher values in the right supramarginal gyrus than the controls. These regions had both high sensitivity and specificity in distinguishing between the two groups suggesting that dysfunction in these regions can be used to correctly classify those individuals who are violent. Dysfunction in the right medial prefrontal-caudate circuit may, therefore, represent an important biomarker of violence juvenile males.

引用

页码：27 / 32

页数：6

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