A comprehensive review on Aurora kinase: Small molecule inhibitors and clinical trial studies

被引:142
作者
Borisa, Ankit C. [1 ]
Bhatt, Hardik G. [1 ]
机构
[1] Nirma Univ, Inst Pharm, Dept Phannaceut Chem, Ahmadabad 382481, India
关键词
Aurora kinase; Aurora-A; Aurora-B; Aurora-C; INCENP; Small molecule inhibitors; CANCER-CELL-LINES; SUPPRESSES TUMOR-GROWTH; A KINASE; POTENT AURORA; IN-VIVO; SELECTIVE AURORA; B-KINASE; ANTITUMOR-ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; PYRIMIDINE-DERIVATIVES;
D O I
10.1016/j.ejmech.2017.08.045
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Aurora kinase belongs to serine/threonine kinase family which controls cell division. Therapeutic inhibition of Aurora kinase showed great promise as probable anticancer regime because of its important role during cell division. Here, in this review, we have carried out exhaustive study of various synthetic molecules reported as Aurora kinase inhibitors and developed as lead molecule at various stages of clinical trials from its discovery in 1995 to till date. We reported details of small molecules, specifically inhibiting all 3 types of Aurora kinases, which includes extensive literature search in various database like various scientific journals, patents, scifinder and PubMed database, internet resources, books, etc. IC50 values of tumor growth inhibition, in-vitro and in-vivo activity along with clinical trial data. Here, we took efforts to describe essence of Aurora kinase and its inhibition which could be used to develop anti mitotic drug for the treatment of cancer. In conclusion, we also discuss future perspectives for development of novel inhibitors and their scope in drug development process. (C) 2017 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:1 / 19
页数:19
相关论文
共 126 条
[1]   Discovery of GSK1070916, a Potent and Selective Inhibitor of Aurora B/C Kinase [J].
Adams, Nicholas D. ;
Adams, Jerry L. ;
Burgess, Joelle L. ;
Chaudhari, Amita M. ;
Copeland, Robert A. ;
Donatelli, Carla A. ;
Drewry, David H. ;
Fisher, Kelly E. ;
Hamajima, Toshihiro ;
Hardwicke, Mary Ann ;
Huffman, William F. ;
Koretke-Brown, Kristin K. ;
Lai, Zhihong V. ;
McDonald, Octerloney B. ;
Nakamura, Hiroko ;
Newlander, Ken A. ;
Oleykowski, Catherine A. ;
Parrish, Cynthia A. ;
Patrick, Denis R. ;
Plant, Ramona ;
Sarpong, Martha A. ;
Sasaki, Kosuke ;
Schmidt, Stanley J. ;
Silva, Domingos J. ;
Sutton, David ;
Tang, Jun ;
Thompson, Christine S. ;
Tummino, Peter J. ;
Wang, Jamin C. ;
Xiang, Hong ;
Yang, Jingsong ;
Dhanak, Dashyant .
JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (10) :3973-4001
[2]   A Class of 2,4-Bisanilinopyrimidine Aurora A Inhibitors with Unusually High Selectivity against Aurora B [J].
Aliagas-Martin, Ignacio ;
Burdick, Dan ;
Corson, Laura ;
Dotson, Jennafer ;
Drummond, Jason ;
Fields, Carter ;
Huang, Oscar W. ;
Hunsaker, Thomas ;
Kleinheinz, Tracy ;
Krueger, Elaine ;
Liang, Jun ;
Moffat, John ;
Phillips, Gail ;
Pulk, Rebecca ;
Rawson, Thomas E. ;
Ultsch, Mark ;
Walker, Leslie ;
Wiesmann, Christian ;
Zhang, Birong ;
Zhu, Bing-Yan ;
Cochran, Andrea G. .
JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (10) :3300-3307
[3]   AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol [J].
Anand, S ;
Penrhyn-Lowe, S ;
Venkitaraman, AR .
CANCER CELL, 2003, 3 (01) :51-62
[4]   Biochemical characterization of GSK1070916, a potent and selective inhibitor of Aurora B and Aurora C kinases with an extremely long residence time [J].
Anderson, Kelly ;
Lai, Zhihong ;
McDonald, Octerloney B. ;
Stuart, J. Darren ;
Nartey, Eldridge N. ;
Hardwicke, Mary Ann ;
Newlander, Ken ;
Dhanak, Dashyant ;
Adams, Jerry ;
Patrick, Denis ;
Copeland, Robert A. ;
Tummino, Peter J. ;
Yang, Jingsong .
BIOCHEMICAL JOURNAL, 2009, 420 :259-265
[5]   3-Cyano-6-(5-methyl-3-pyrazoloamino)pyridines: Selective Aurora A kinase inhibitors [J].
Ando, Ryoichi ;
Ikegami, Hiroshi ;
Sakiyama, Makoto ;
Ooike, Shinsuke ;
Hayashi, Masayuki ;
Fujino, Yasuhiro ;
Abe, Daisuke ;
Nakamura, Hideo ;
Mishina, Tadashi ;
Kato, Harutoshi ;
Iwase, Yumiko ;
Tomozane, Hideo ;
Morioka, Masahiko .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (15) :4709-4711
[6]  
Andrew S., 2010, ACH ANN M ABSTR, V116
[7]   Aurora kinases: shining lights on the therapeutic horizon? [J].
Andrews, PD .
ONCOGENE, 2005, 24 (32) :5005-5015
[8]  
[Anonymous], [No title captured], Patent No. 0236564
[9]  
Arbitrario J. P., 2010, PHARMACOLOGY, V65, P707
[10]   Effects of the Aurora kinase inhibitor VX-680 on anaplastic thyroid cancer-derived cell lines [J].
Arlot-Bonnemains, Yannick ;
Baldini, Enke ;
Martin, Benedicte ;
Delcros, Jean-Guy ;
Toller, Matteo ;
Curcio, Francesco ;
Ambesi-Impiombato, Francesco S. ;
D'Armiento, Massimino ;
Ulisse, Salvatore .
ENDOCRINE-RELATED CANCER, 2008, 15 (02) :559-568