Biomarkers to predict the clinical efficacy of bevacizumab in cancer

被引：262

作者：

Jubb, Adrian M. ^{[1
]}

Harris, Adrian L. ^{[1
]}

机构：

[1] Univ Oxford, Weatherall Inst Mol Med, Oxford OX3 9DS, England

来源：

LANCET ONCOLOGY | 2010年 / 11卷 / 12期

关键词：

ENDOTHELIAL GROWTH-FACTOR; METASTATIC COLORECTAL-CANCER; ADVANCED BREAST-CANCER; PACLITAXEL PLUS BEVACIZUMAB; ANTI-VEGF THERAPY; PHASE-III TRIAL; BLOOD-PRESSURE; TUMOR REFRACTORINESS; CELL MOBILIZATION; 1ST-LINE THERAPY;

D O I：

10.1016/S1470-2045(10)70232-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bevacizumab is a monoclonal antibody against vascular endothelial growth factor that has antiangiogenic activity and Improves progression free survival in many solid malignancies when combined with cytotoxic chemotherapy but has little effect on overall survival Despite the effects of this drug in unselected patients the Response Evaluation Criteria in Solid Tumours are suboptimum to predict benefit Additionally, tumours show inherent and emerging resistance to regimens that include bevacizumab The ability to target therapy towards well selected subgroups of patients would Increase the likelihood of benefits and would improve cost effectiveness and therapeutic outcomes In this review we discuss putative clinical radiological and molecular markers of bevacizumab efficacy, derived from data obtained in clinical trials Current evidence indicates some predictive value for hypertension vascular imaging and polymorphisms affecting components of the vascular endothelial growth factor pathway in patients receiving bevacizumab Many questions relating to these and other surrogate biomarkers, however, remain unanswered and their clinical usefulness has yet to be proven

引用

页码：1172 / 1183

页数：12

共 90 条

[1]

[Anonymous], J CLIN ONCOL

[2] A Vasculature-Targeting Regimen of Preoperative Docetaxel with or without Bevacizumab for Locally Advanced Breast Cancer: Impact on Angiogenic Biomarkers [J].

Baar, Joseph ;

Silverman, Paula ;

Lyons, Janice ;

Fu, Pingfu ;

Abdul-Karim, Fadi ;

Ziats, Nicholas ;

Wasman, Jay ;

Hartman, Paul ;

Jesberger, John ;

Dumadag, Leda ;

Hohler, Erin ;

Leeming, Rosemary ;

Shenk, Robert ;

Chen, Helen ;

McCrae, Keith ;

Dowlati, Afshin ;

Remick, Scot C. ;

Overmoyer, Beth .

CLINICAL CANCER RESEARCH, 2009, 15 (10) :3583-3590

[3] Circulating vascular endothelial growth factor (VEGF) as a biomarker for bevacizumab-based therapy in metastatic colorectal, non-small cell lung, and renal cell cancers: Analysis of phase III studies [J].

Bernaards, C. ;

Hegde, P. ;

Chen, D. ;

Holmgren, E. ;

Zheng, M. ;

Jubb, A. M. ;

Koeppen, H. ;

Scherer, S. J. ;

Chen, D. S. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15)

[4] Hypertension and clinical benefit of bevacizumab in the treatment of advanced renal cell carcinoma [J].

Bono, P. ;

Elfving, H. ;

Utriainen, T. ;

Osterlund, P. ;

Saarto, T. ;

Alanko, T. ;

Joensuu, H. .

ANNALS OF ONCOLOGY, 2009, 20 (02) :393-394

[5] Neoadjuvant treatment of colorectal cancer with bevacizumab: The perioperative angiogenic balance is sensitive to systemic thrombospondin-1 levels [J].

Brostjan, Christine ;

Gebhardt, Kristina ;

Gruenberger, Birgit ;

Steinrueck, Verena ;

Zommer, Halina ;

Freudenthaler, Harald ;

Roka, Sebastian ;

Gruenberger, Thomas .

CLINICAL CANCER RESEARCH, 2008, 14 (07) :2065-2074

[6]

Brufsky A, 2010, J CLIN ONCOL, V28

[7] VEGF as a Marker for Outcome Among Advanced Breast Cancer Patients Receiving anti-VEGF Therapy with Bevacizumab and Vinorelbine Chemotherapy [J].

Burstein, Harold J. ;

Chen, Yu-Hui ;

Parker, Leroy M. ;

Savoie, Jennifer ;

Younger, Jerry ;

Kuter, Irene ;

Ryan, Paula D. ;

Garber, Judy E. ;

Chen, Helen ;

Campos, Susana M. ;

Shulman, Lawrence N. ;

Harris, Lyndsay N. ;

Gelman, Rebecca ;

Winer, Eric P. .

CLINICAL CANCER RESEARCH, 2008, 14 (23) :7871-7877

[8]

CHAN A, 2008, 31 SAN ANT BREAST CA

[9] Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography:: A pilot study [J].

Chen, Wei ;

Delaloye, Sibylle ;

Silverman, Daniel H. S. ;

Geist, Cheri ;

Czernin, Johannes ;

Sayre, James ;

Satyamurthy, Nagichettiar ;

Pope, Whitney ;

Lai, Albert ;

Phelps, Michael E. ;

Cloughesy, Timothy .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (30) :4714-4721

[10] Association of Computed Tomography Morphologic Criteria With Pathologic Response and Survival in Patients Treated With Bevacizumab for Colorectal Liver Metastases [J].

Chun, Yun Shin ;

Vauthey, Jean-Nicolas ;

Boonsirikamchai, Piyaporn ;

Maru, Dipen M. ;

Kopetz, Scott ;

Palavecino, Martin ;

Curley, Steven A. ;

Abdalla, Eddie K. ;

Kaur, Harmeet ;

Charnsangavej, Chusilp ;

Loyer, Evelyne M. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2009, 302 (21) :2338-2344

← 1 2 3 4 5 6 7 8 9 →