Synthetic flavone derivatives. An antibacterial evaluation and structure-activity relationship study

被引：0

作者：

Shoaib, M. ^{[1
]}

Shah, S. W. A. ^{[1
]}

Ali, N. ^{[2
]}

Shah, I. ^{[1
]}

Umar, M. N. ^{[3
]}

Shafiullah ^{[1
]}

Tahir, M. N. ^{[4
]}

Ghias, M. ^{[1
]}

机构：

[1] Univ Malakand, Dept Pharm, Dir Lower 18550, Khyber Pakhtunk, Pakistan

[2] Khyber Med Univ, Inst Basic Med Sci, Dept Pharmacol, Peshawar 25000, Khyber Pakhtunk, Pakistan

[3] Univ Malakand, Dept Chem, Dir Lower 18550, Khyber Pakhtunk, Pakistan

[4] Univ Sargodha, Dept Phys, Sargodha 40100, Punjab, Pakistan

来源：

BULGARIAN CHEMICAL COMMUNICATIONS | 2016年 / 48卷 / 03期

关键词：

Flavone derivatives; antibacterial; MIC; infectious diseases; ANTIMICROBIAL ACTIVITY; AGENTS; PLANTS; ANTIFUNGAL; CHROMONES;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biologically active flavone derivatives with. antibacterial potentials were synthesized via Claisen-Schmidt condensation of ketones with different aldehydes with good yields. The structures were established by, different spectroscopic techniques like H-1 NMR, C-13 NMR, IR and elemental analysis. The findings showed that some of the substituted flavones possess higher antibacterial potentials than simple flavones as regards their minimum inhibitory concentration (MIC) and are potential candidates for the treatment of a wide range of infectious diseases.

引用

页码：414 / 421

页数：8

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