TPC2 targeting evolution: Leveraging therapeutic opportunities for cancer

被引：5
作者：
Alharbi, Abeer F. [1 ,2 ]
Parrington, John [1 ]
机构：
[1] Univ Oxford, Dept Pharmacol, Oxford, England
[2] King Saud Bin Abdul Aziz Univ Hlth Sci, Pharmaceut Sci Dept, Coll Pharm, Riyadh, Saudi Arabia
来源：
CELL CHEMICAL BIOLOGY | 2021年 / 28卷 / 08期
关键词：
D O I：
10.1016/j.chembiol.2021.07.020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Growing evidence implicates a vital role for TPC2/Ca2+ signaling in pathophysiological processes attributed to cancer, raising questions regarding the utility of TPC2 as a cancer therapeutic target. In this issue of Cell Chemical Biology, Muller et al. (2021) develop TPC2 inhibitors, SG005 and SG-094, exhibiting anti-tumor effects with potential translational relevance.
引用
收藏
页码：1103 / 1105
页数：4
相关论文
共 9 条
  • [1] Endolysosomal Ca2+ Signaling in Cancer: The Role of TPC2, From Tumorigenesis to Metastasis
    Alharbi, Abeer F.
    Parrington, John
    [J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019, 7
  • [2] Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Induces Intracellular Ca2+ Release through the Two-Pore Channel TPC1 in Metastatic Colorectal Cancer Cells
    Faris, Pawan
    Pellavio, Giorgia
    Ferulli, Federica
    Di Nezza, Francesca
    Shekha, Mudhir
    Lim, Dmitry
    Maestri, Marcello
    Guerra, Germano
    Ambrosone, Luigi
    Pedrazzoli, Paolo
    Laforenza, Umberto
    Montagna, Daniela
    Moccia, Francesco
    [J]. CANCERS, 2019, 11 (04)
  • [3] KANE J, 1978, AM J PSYCHIAT, V135, P1539
  • [4] Two-pore channels (TPCs): Current controversies
    Morgan, Anthony J.
    Galione, Antony
    [J]. BIOESSAYS, 2014, 36 (02) : 173 - 183
  • [5] Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth
    Mueller, Martin
    Gerndt, Susanne
    Chao, Yu-Kai
    Zisis, Themistoklis
    Ong Nam Phuong Nguyen
    Gerwien, Aaron
    Urban, Nicole
    Mueller, Christoph
    Gegenfurtner, Florian A.
    Geisslinger, Franz
    Ortler, Carina
    Chen, Cheng-Chang
    Zahler, Stefan
    Biel, Martin
    Schaefer, Michael
    Grimm, Christian
    Bracher, Franz
    Vollmar, Angelika M.
    Bartel, Karin
    [J]. CELL CHEMICAL BIOLOGY, 2021, 28 (08) : 1119 - +
  • [6] NCBI, 2021, TPCN2 2 POR SEGM CHA
  • [7] Naringenin Impairs Two-Pore Channel 2 Activity And Inhibits VEGF-Induced Angiogenesis
    Pafumi, Irene
    Festa, Margherita
    Papacci, Francesca
    Lagostena, Laura
    Giunta, Cristina
    Gutla, Vijay
    Cornara, Laura
    Favia, Annarita
    Palombi, Fioretta
    Gambale, Franco
    Filippini, Antonio
    Carpaneto, Armando
    [J]. SCIENTIFIC REPORTS, 2017, 7
  • [8] Knock-Down of Mucolipin 1 Channel Promotes Tumor Progression and Invasion in Human Glioblastoma Cell Lines
    Santoni, Giorgio
    Amantini, Consuelo
    Nabissi, Massimo
    Maggi, Federica
    Arcella, Antonietta
    Marinelli, Oliviero
    Eleuteri, Anna Maria
    Santoni, Matteo
    Morelli, Maria Beatrice
    [J]. FRONTIERS IN ONCOLOGY, 2021, 11
  • [9] the 11q13-q14 amplicon: Clinicopathological correlations and potential drivers
    Wilkerson, Paul M.
    Reis-Filho, Jorge S.
    [J]. GENES CHROMOSOMES & CANCER, 2013, 52 (04) : 333 - 355
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