Pretreatment inflammatory markers predicting treatment outcomes in colorectal cancer

被引:37
作者
An, Sanghyun [1 ]
Shim, Hongjin [1 ]
Kim, Kwangmin [1 ]
Kim, Bora [2 ]
Bang, Hui-Jae [3 ]
Do, Hyejin [4 ]
Lee, Hyang-Rae [5 ]
Kim, Youngwan [1 ]
机构
[1] Yonsei Univ, Dept Surg, Wonju Coll Med, 20 Ilsan Ro, Wonju 26426, South Korea
[2] Yonsei Univ, Dept Internal Med, Div Gastroenterol, Wonju Coll Med, Wonju, South Korea
[3] Konkuk Univ, Dept Surg, Chungju Hosp, Chungju, South Korea
[4] Yonsei Univ, Dept Anesthesiol, Wonju Coll Med, Wonju, South Korea
[5] Yonsei Univ, Dept Family Med, Wonju Coll Med, Wonju, South Korea
基金
新加坡国家研究基金会;
关键词
Colonic neoplasms; Rectal neoplasms; Inflammation; Biomarkers; Prognosis; C-REACTIVE PROTEIN; NEUTROPHIL-LYMPHOCYTE RATIO; TO-ALBUMIN RATIO; PREOPERATIVE NEUTROPHIL; RECTAL-CANCER; CLINICAL-SIGNIFICANCE; NEOADJUVANT CHEMORADIATION; PROGNOSTIC-SIGNIFICANCE; SYSTEMIC INFLAMMATION; CURATIVE RESECTION;
D O I
10.3393/ac.2021.01004.0143
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
We aimed to review whether pretreatment inflammatory markers reflect the short- and long-term outcomes of patients with colon cancer, rectal cancer, colon and rectal cancers, and metastatic colorectal cancer (CRC). We found that pretreatment complete blood count and blood chemistry tests reflect short-term and long-term oncological outcomes in patients with CRC. Specifically, in patients with colon cancer, hypoalbuminemia was associated with worse postoperative morbidity, mortality, and inferior survival. In patients with rectal cancer, elevated neutrophil-lymphocyte ratio (NLR) and thrombocytosis were associated with postoperative complications, poor overall survival (OS), and disease-free survival (DFS). A high C-reactive protein/albumin ratio (CAR) was associated with poor OS and DFS. In patients with metastatic CRC, increased NLR and platelet-lymphocyte ratio (PLR) were associated with poor OS, DFS, and progression-free survival (PFS). In addition, high CAR and a low albumin/globulin ratio on blood chemistry tests were associated with poor OS and PFS. Although universal cut-off values were not available, various types of pretreatment laboratory markers could be utilized as adjuncts to predict prognosis in patients with CRC.
引用
收藏
页码:97 / 108
页数:12
相关论文
共 91 条
[1]   Prognostic Impact of Neutrophil/Lymphocyte Ratio, Platelet Count, CRP, and Albumin Levels in Metastatic Colorectal Cancer Patients Treated with FOLFIRI-Bevacizumab [J].
Artaç M. ;
Uysal M. ;
Karaağaç M. ;
Korkmaz L. ;
Er Z. ;
Güler T. ;
Börüban M.C. ;
Bozcuk H. .
Journal of Gastrointestinal Cancer, 2017, 48 (2) :176-180
[2]   The value of the pretreatment albumin/globulin ratio in predicting the long-term survival in colorectal cancer [J].
Azab, Basem ;
Kedia, Shiksha ;
Shah, Neeraj ;
Vonfrolio, Steven ;
Lu, William ;
Naboush, Ali ;
Mohammed, Farhan ;
Bloom, Scott W. .
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2013, 28 (12) :1629-1636
[3]   Elevated platelet count is a negative predictive and prognostic marker in locally advanced rectal cancer undergoing neoadjuvant chemoradiation: a retrospective multi-institutional study on 965 patients [J].
Belluco, Claudio ;
Forlin, Marco ;
Delrio, Paolo ;
Rega, Daniela ;
Degiuli, Maurizio ;
Sofia, Silvia ;
Olivieri, Matteo ;
Pucciarelli, Salvatore ;
Zuin, Matteo ;
De Manzoni, Giovanni ;
Di Leo, Alberto ;
Scabini, Stefano ;
Zorcolo, Luigi ;
Restivo, Angelo .
BMC CANCER, 2018, 18
[4]  
Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21492, 10.3322/caac.21609]
[5]   Neutrophil to Lymphocyte Ratio (NLR) and Derived Neutrophil to Lymphocyte Ratio (d-NLR) Predict Non-Responders and Postoperative Complications in Patients Undergoing Radical Surgery After Neo-Adjuvant Radio-Chemotherapy for Rectal Adenocarcinoma [J].
Caputo, Damiano ;
Caricato, Marco ;
Coppola, Alessandro ;
La Vaccara, Vincenzo ;
Fiore, Michele ;
Coppola, Roberto .
CANCER INVESTIGATION, 2016, 34 (09) :440-451
[6]   Systemic inflammatory response is a predictor of outcome in patients undergoing preoperative chemoradiation for locally advanced rectal cancer [J].
Carruthers, R. ;
Tho, L. M. ;
Brown, J. ;
Kakumanu, S. ;
McCartney, E. ;
McDonald, A. C. .
COLORECTAL DISEASE, 2012, 14 (10) :E701-E707
[7]   Prognostic role of a new inflammatory index with neutrophil-to-lymphocyte ratio and lactate dehydrogenase (CII: Colon Inflammatory Index) in patients with metastatic colorectal cancer: results from the randomized Italian Trial in Advanced Colorectal Cancer (ITACa) study [J].
Casadei-Gardini, Andrea ;
Scarpi, Emanuela ;
Ulivi, Paola ;
Palladino, Maria Angela ;
Accettura, Caterina ;
Bernardini, Ilaria ;
Spallanzani, Andrea ;
Gelsomino, Fabio ;
Corbelli, Jody ;
Marisi, Giorgia ;
Ruscelli, Silvia ;
Valgiusti, Martina ;
Frassineti, Giovanni Luca ;
Passardi, Alessandro .
CANCER MANAGEMENT AND RESEARCH, 2019, 11 :4357-4369
[8]   Pre-treatment lymphopenia as a prognostic biomarker in colorectal cancer patients receiving chemotherapy [J].
Ceze, N. ;
Thibault, G. ;
Goujon, G. ;
Viguier, J. ;
Watier, H. ;
Dorval, E. ;
Lecomte, T. .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2011, 68 (05) :1305-1313
[9]   Pre-operative serum albumin level substantially predicts post-operative morbidity and mortality among patients with colorectal cancer who undergo elective colectomy [J].
Chiang, J. M. ;
Chang, C. J. ;
Jiang, S. F. ;
Yeh, C. Y. ;
You, J. F. ;
Hsieh, P. S. ;
Huang, H. Y. .
EUROPEAN JOURNAL OF CANCER CARE, 2017, 26 (02)
[10]   Can neutrophil-to-lymphocyte ratio predict the survival of colorectal cancer patients who have received curative surgery electively? [J].
Chiang, Sum-Fu ;
Hung, Hsin-Yuan ;
Tang, Reiping ;
Chung Rong Changchien ;
Chen, Jinn-Shiun ;
You, Yau-Tong ;
Chiang, Jy-Ming ;
Lin, Jr-Rung .
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2012, 27 (10) :1347-1357