Nephroprotective effect of vanillic acid against cisplatin induced nephrotoxicity in wistar rats: A biochemical and molecular study

被引：75

作者：

Sindhu, Ganapathy ^{[1
]}

Nishanthi, Emayavaramban ^{[1
]}

Sharmila, Ramalingam ^{[1
]}

机构：

[1] Annamalai Univ, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2015年 / 39卷 / 01期

关键词：

Cisplatin; Vanillic acid; Nephroprotective; TNF-alpha; NF-kappa B; Antioxidants; NF-KAPPA-B; ACUTE-RENAL-FAILURE; PHENOLIC-ACIDS; TNF-ALPHA; INFLAMMATION; KIDNEY; INJURY; LYMPHOCYTES; INHIBITION; EXPRESSION;

D O I：

10.1016/j.etap.2014.12.008

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Cisplatin is one of the extensively used anticancer drugs against various cancers. Dosage dependent nephrotoxicity is the major problem in cisplatin chemotherapy. Cisplatin induced nephrotoxicity results in the depletion of renal antioxidant defence system. Our present study is aimed to investigate the nephroprotective effect of vanilic acid to against cisplatin induced nephrotoxicity in male wistar rats. Elevated levels of serum creatinine, blood urea nitrogen, serum uric acid and reduced antioxidant status were observed as indicatives of nephrotoxicity in cisplatin (7 mg/kg bw) alone administered rats. Animals which are pre-treated with vanillic acid (50 mg/kg and 100 mg/kg) restored the elevated levels of renal function markers and reduced antioxidant status to near normalcy when compared to cisplatin alone treated animals. Cisplatin induced lipid peroxidation was markedly reduced by oral administration of vanillic acid at a high dose. The findings in the present study suggest that vanillic acid is a potential antioxidant that reduce cisplatin nephrotoxicity and can be as a combinatorial regimen in cancer chemotherapy. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：392 / 404

页数：13

共 62 条

[1]

[Anonymous], J SCI TECHNOL

[2] Cisplatin nephrotoxicity [J].

Arany, I ;

Safirstein, RL .

SEMINARS IN NEPHROLOGY, 2003, 23 (05) :460-464

[3] Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing NFκB, TNF-α and caspase-3 expression in wistar rats [J].

Arjumand, Wani ;

Seth, Amlesh ;

Sultana, Sarwat .

FOOD AND CHEMICAL TOXICOLOGY, 2011, 49 (09) :2013-2021

[4] Phenotypic and functional characterization of kidney-infiltrating lymphocytes in renal ischemia reperfusion injury [J].

Ascon, Dolores B. ;

Lopez-Briones, Sergio ;

Liu, Manchang ;

Ascon, Miguel ;

Savransky, Vladimir ;

Colvin, Robert B. ;

Soloski, Mark J. ;

Rabb, Hamid .

JOURNAL OF IMMUNOLOGY, 2006, 177 (05) :3380-3387

[5] Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion [J].

Bamboat, Zubin M. ;

Ocuin, Lee M. ;

Balachandran, Vinod P. ;

Obaid, Hebroon ;

Plitas, George ;

DeMatteo, Ronald P. .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (02) :559-569

[6]

BONSNES RW, 1945, J BIOL CHEM, V158, P581

[7]

BROWN H, 1945, J BIOL CHEM, V158, P601

[8] Antioxidative characteristics and inhibition of α-melanocyte-stimulating hormone-stimulated melanogenesis of vanillin and vanillic acid from Origanum vulgare [J].

Chou, Tzung-Han ;

Ding, Hsiou-Yu ;

Hung, Wei Jing ;

Liang, Chia-Hua .

EXPERIMENTAL DERMATOLOGY, 2010, 19 (08) :742-750

[9] Naturally occurring phenolic acids inhibit 12-O-tetradecanoylphorbol-13-acetate induced NF-κB, iNOS and COX-2 activation in mouse epidermis [J].

Cichocki, Michal ;

Blumczynska, Joanna ;

Baer-Dubowska, Wanda .

TOXICOLOGY, 2010, 268 (1-2) :118-124

[10] TRANSCRIPTIONAL REGULATION OF ENDOTHELIAL-CELL ADHESION MOLECULES - NF-KAPPA-B AND CYTOKINE-INDUCIBLE ENHANCERS [J].

COLLINS, T ;

READ, MA ;

NEISH, AS ;

WHITLEY, MZ ;

THANOS, D ;

MANIATIS, T .

FASEB JOURNAL, 1995, 9 (10) :899-909

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