Synergistic Engineering: Organoids Meet Organs-on-a-Chip

被引：200

作者：

Takebe, Takanori ^{[1
,2
,3
]}

Zhang, Boyang ^{[5
]}

Radisic, Milica ^{[4
,5
,6
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

[2] Cincinnati Childrens Hosp Med Ctr, Ctr Stem Cell & Organoid Med CuSTOM, Cincinnati, OH 45229 USA

[3] Yokohama City Univ, Dept Regenerat Med, Yokohama, Kanagawa, Japan

[4] Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON, Canada

[5] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON, Canada

[6] Univ Hlth Network, Toronto Gen Res Inst, Toronto, ON, Canada

来源：

CELL STEM CELL | 2017年 / 21卷 / 03期

关键词：

HUMAN BRAIN ORGANOIDS; SELF-ORGANIZATION; DYNAMICS;

D O I：

10.1016/j.stem.2017.08.016

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Organoid technology and organ-on-a-chip engineering have emerged as two distinct approaches for stem cell-derived 3D tissue preparation. Their strategic integration can address each approach's limitations and provide a path toward a superior, synergistic strategy of constructing tissues that will truly deliver on the promise of regenerative and precision medicine.

引用

收藏

页码：297 / 300

页数：4

相关论文

共 10 条

[1] Reconstituting Organ-Level Lung Functions on a Chip [J].

Huh, Dongeun ;

Matthews, Benjamin D. ;

Mammoto, Akiko ;

Montoya-Zavala, Martin ;

Hsin, Hong Yuan ;

Ingber, Donald E. .

SCIENCE, 2010, 328 (5986) :1662-1668

[2] Guided self-organization and cortical plate formation in human brain organoids [J].

Lancaster, Madeline A. ;

Corsini, Nina S. ;

Wolfinger, Simone ;

Gustafson, E. Hilary ;

Phillips, Alex W. ;

Burkard, Thomas R. ;

Otani, Tomoki ;

Livesey, Frederick J. ;

Knoblich, Juergen A. .

NATURE BIOTECHNOLOGY, 2017, 35 (07) :659-+

[3] Organogenesis in a dish: Modeling development and disease using organoid technologies [J].

Lancaster, Madeline A. ;

Knoblich, Juergen A. .

SCIENCE, 2014, 345 (6194)

[4] Design and Demonstration of a Pumpless 14 Compartment Microphysiological System [J].

Miller, Paula G. ;

Shuler, Michael L. .

BIOTECHNOLOGY AND BIOENGINEERING, 2016, 113 (10) :2213-2227

[5]

Nunes SS, 2013, NAT METHODS, V10, P781, DOI [10.1038/nmeth.2524, 10.1038/NMETH.2524]

[6] Cell diversity and network dynamics in photosensitive human brain organoids [J].

Quadrato, Giorgia ;

Tuan Nguyen ;

Macosko, Evan Z. ;

Sherwood, John L. ;

Yang, Sung Min ;

Berger, Daniel R. ;

Maria, Natalie ;

Scholvin, Jorg ;

Goldman, Melissa ;

Kinney, Justin P. ;

Boyden, Edward S. ;

Lichtman, Jeff W. ;

Williams, Ziv M. . ;

McCarroll, Steven A. ;

Arlotta, Paola .

NATURE, 2017, 545 (7652) :48-+

[7] Cytosystems dynamics in self-organization of tissue architecture [J].

Sasai, Yoshiki .

NATURE, 2013, 493 (7432) :318-326

[8] Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation [J].

Takebe, Takanori ;

Enomura, Masahiro ;

Yoshizawa, Emi ;

Kimura, Masaki ;

Koike, Hiroyuki ;

Ueno, Yasuharu ;

Matsuzaki, Takahisa ;

Yamazaki, Takashi ;

Toyohara, Takafumi ;

Osafune, Kenji ;

Nakauchi, Hiromitsu ;

Yoshikawa, Hiroshi Y. ;

Taniguchi, Hideki .

CELL STEM CELL, 2015, 16 (05) :556-565

[9] Vascularized and functional human liver from an iPSC-derived organ bud transplant [J].

Takebe, Takanori ;

Sekine, Keisuke ;

Enomura, Masahiro ;

Koike, Hiroyuki ;

Kimura, Masaki ;

Ogaeri, Takunori ;

Zhang, Ran-Ran ;

Ueno, Yasuharu ;

Zheng, Yun-Wen ;

Koike, Naoto ;

Aoyama, Shinsuke ;

Adachi, Yasuhisa ;

Taniguchi, Hideki .

NATURE, 2013, 499 (7459) :481-+

[10]

Zhang BY, 2016, NAT MATER, V15, P669, DOI [10.1038/NMAT4570, 10.1038/nmat4570]