4-HYDROXY-2-QUINOLONES. 176. 4-R-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDS. SYNTHESIS, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES

被引：15
|
作者：
Ukrainets, I. V. [1 ]
Davidenko, A. A. [2 ]
Mospanova, E. V. [3 ]
Sidorenko, L. V. [1 ]
Svechnikova, E. N. [1 ]
机构：
[1] Natl Univ Pharm, UA-61002 Kharkov, Ukraine
[2] NI Pirogov Vinitsa Natl Med Univ, UA-21018 Vinnitsa, Ukraine
[3] V Dal East Ukrainian Natl Univ, Inst Chem Technol, UA-93003 Rubizhne, Ukraine
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2010年 / 46卷 / 05期
关键词：
4-R-2-oxo-1,2-dihydroquinoline-3-carboxylic acids; pKa; analgesic activity; hydrolysis;
D O I：
10.1007/s10593-010-0546-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have carried out the synthesis and a comparative analysis of the acidic properties of a large group of 4-R-2-oxo-1,2-dihydroquinoline-3-carboxylic acids. Features of the recorded NMR spectra of these compounds are discussed together with their analgesic properties.
引用
收藏
页码：559 / 568
页数：10
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