A new and 23 known cardenolide glycosides from Thevetia neriifolia seeds and their cytotoxic activities against human oral carcinoma cell lines

被引：2

作者：

Tatsuno, Satoru ^{[1
]}

Iguchi, Tomoki ^{[1
]}

Kuroda, Minpei ^{[1
]}

Ishihara, Mai ^{[1
]}

Sakagami, Hiroshi ^{[2
]}

Mimaki, Yoshihiro ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Dept Med Pharmacognosy, Sch Pharm, Hachioji, Tokyo, Japan

[2] Meikai Univ, Res Inst Odontol M RIO, Sakado, Saitama, Japan

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 22期

关键词：

Thevetia neriifolia; Apocynaceae; seed; cardenolide glycoside; cytotoxic activity; oral carcinoma cell; CARDIAC-GLYCOSIDES; TRITERPENOID SAPONINS; CERBERA-ODOLLAM; LEAVES; CONSTITUENTS; PERUVIANA;

D O I：

10.1080/14786419.2020.1716352

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Phytochemical analysis of Thevetia neriifolia seeds resulted in the isolation of one new (1) and 23 known (224) cardenolide glycosides. The structure of 1 was determined based on one- and two-dimensional NMR spectroscopic analysis and acid hydrolytic cleavage reaction. The effect of the cytotoxic activity of 124 on three human oral carcinoma cell lines was assessed. The cell lines included Ca9-22 human gingival carcinoma cells, HSC-2 human mouth carcinoma cells, HSC-4 human tongue carcinoma cells, and HGF human gingival fibroblast cells. The isolated compounds had a cytotoxic effect on the carcinoma cells with IC50 values ranging from 0.004 mu M to 64.9 mu M. The structure-activity relationship is also discussed.

引用

页码：4388 / 4393

页数：6

共 43 条

[41] Crispoic acid, a new compound from Laelia marginata (Orchidaceae), and biological evaluations against parasites, human cancer cell lines and Zika virus
Belloto, Andrezza C.
Souza, Gredson K.
Perin, Paula C.
Schuquel, Ivania T. A.
Santin, Silvana M. O.
Chiavelli, Lucas U. R.
Garcia, Francielle P.
Kaplum, Vanessa
Rodrigues, Jean H. S.
Scariot, Debora B.
Delvecchio, Rodrigo
Machado-Ferreira, Erik
Aguiar, Renato Santana
Soares, Carlos A. G.
Nakamura, Celso V.
Pomini, Armando M.
NATURAL PRODUCT RESEARCH, 2018, 32 (24) : 2916 - 2921
[42] Isolation of a new monoterpenoid glycoside from Anhua dark tea based on an NMR-guided method and its cytotoxic activity against MDA-MB-231 and SH-SY5Y cell lines
Zhang, Yunqiang
Liu, Jianyu
Chen, Miao
Fan, Yanhua
Li, Meichen
Wang, Andong
Liu, Gaigai
Xu, Yongnan
Ren, Xuhong
Xiao, Yan
NATURAL PRODUCT RESEARCH, 2022, 36 (08) : 2015 - 2020
[43] A comparison of the anti-proliferative activity of Carica papaya L. extracts obtained from bioreactor and field roots against Caco-2 and HeLa human carcinoma cell lines
Jamieson, N.
Shalom, J.
Drew, R.
Cock, I.
FRUITS, 2023, 78 (01)

← 1 2 3 4 5 →