A new and 23 known cardenolide glycosides from Thevetia neriifolia seeds and their cytotoxic activities against human oral carcinoma cell lines

被引：2
|
作者：
Tatsuno, Satoru [1 ]
Iguchi, Tomoki [1 ]
Kuroda, Minpei [1 ]
Ishihara, Mai [1 ]
Sakagami, Hiroshi [2 ]
Mimaki, Yoshihiro [1 ]
机构：
[1] Tokyo Univ Pharm & Life Sci, Dept Med Pharmacognosy, Sch Pharm, Hachioji, Tokyo, Japan
[2] Meikai Univ, Res Inst Odontol M RIO, Sakado, Saitama, Japan
来源：
NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 22期
关键词：
Thevetia neriifolia; Apocynaceae; seed; cardenolide glycoside; cytotoxic activity; oral carcinoma cell; CARDIAC-GLYCOSIDES; TRITERPENOID SAPONINS; CERBERA-ODOLLAM; LEAVES; CONSTITUENTS; PERUVIANA;
D O I：
10.1080/14786419.2020.1716352
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Phytochemical analysis of Thevetia neriifolia seeds resulted in the isolation of one new (1) and 23 known (224) cardenolide glycosides. The structure of 1 was determined based on one- and two-dimensional NMR spectroscopic analysis and acid hydrolytic cleavage reaction. The effect of the cytotoxic activity of 124 on three human oral carcinoma cell lines was assessed. The cell lines included Ca9-22 human gingival carcinoma cells, HSC-2 human mouth carcinoma cells, HSC-4 human tongue carcinoma cells, and HGF human gingival fibroblast cells. The isolated compounds had a cytotoxic effect on the carcinoma cells with IC50 values ranging from 0.004 mu M to 64.9 mu M. The structure-activity relationship is also discussed.
引用
收藏
页码：4388 / 4393
页数：6
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