Symmetry Breaking in the Mammalian Embryo

被引：43

作者：

Zhang, Hui Ting ^{[1
]}

Hiiragi, Takashi ^{[1
]}

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 34 | 2018年 / 34卷

关键词：

symmetry breaking; mammalian development; self-organization; ANTERIOR-POSTERIOR AXIS; INNER CELL MASS; EARLY MOUSE EMBRYO; PRIMITIVE ENDODERM; VISCERAL ENDODERM; LINEAGE SEGREGATION; GENE-EXPRESSION; FATE DECISIONS; IN-VITRO; DEVELOPMENTAL HISTORY;

D O I：

10.1146/annurev-cellbio-100617-062616

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We present an overview of symmetry breaking in early mammalian development as a continuous process from compaction to specification of the body axes. While earlier studies have focused on individual symmetry-breaking events, recent advances enable us to explore progressive symmetry breaking during early mammalian development. Although we primarily discuss embryonic development of the mouse, as it is the best-studied mammalian model system to date, we also highlight the shared and distinct aspects between different mammalian species. Finally, we discuss how insights gained from studying mammalian development can be generalized in light of self-organization principles. With this review, we hope to highlight new perspectives in studying symmetry breaking and self-organization in multicellular systems.

引用

页码：405 / 426

页数：22

共 164 条

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