Monitoring chemically enhanced transdermal delivery pathways of luminescent quantum dots by multiphoton microscopy

被引：1
作者：
Lo, W [1 ]
Tso, CH [1 ]
Huang, PY [1 ]
Hsu, CL [1 ]
Yeh, CC [1 ]
Lin, SJ [1 ]
Jee, SH [1 ]
Chen, CC [1 ]
Dong, CY [1 ]
机构：
[1] Natl Taiwan Univ, Dept Phys, Taipei 106, Taiwan
来源：
APBP 2004: SECOND ASIAN AND PACIFIC RIM SYMPOSIUM ON BIOPHOTONICS, PROCEEDINGS | 2004年
关键词：
D O I：
10.1109/APBP.2004.1412285
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Luminescent quantum dots (QDs) are attractive fluorescent probes in bioimaging application. In this work, we investigate the feasibility of administering QDs (7 nm in size) through transdermal delivery pathway using multiphoton fluorescence imaging. Our results show that QDs of this size range can be effectively delivered through intercellular pathways using the chemical enhancer oleic acid. This work has implications for understanding the transport of important biological macromolecules. Our results suggest that QDs can be non-invasively delivered for biological imaging and for probing the transport of nanometer-scale material in tissue. These results also imply that the size of nanoparticles may dominate the nature of transdermal transport mechanism.
引用
收藏
页码：74 / 75
页数：2
相关论文
共 50 条
[11]   Effects of absorption saturation in colloidal quantum dots as fluorophores for multiphoton fluorescence microscopy [J].
A. R. Katichev ;
E. A. Sergeeva .
Optics and Spectroscopy, 2009, 107 :839-845
[12]   Multiphoton microscopy based on four-wave mixing of colloidal quantum dots [J].
Masia, Francesco ;
Langbein, Wolfgang ;
Borri, Paola .
APPLIED PHYSICS LETTERS, 2008, 93 (02)
[13]   Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles [J].
Lo, Wen ;
Ghazaryan, Ara ;
Tso, Chien-Hsin ;
Hu, Po-Sheng ;
Chen, Wei-Liang ;
Kuo, Tsung-Rong ;
Lin, Sung-Jan ;
Chen, Shean-Jen ;
Chen, Chia-Chun ;
Dong, Chen-Yuan .
APPLIED PHYSICS LETTERS, 2012, 100 (21)
[14]   Transdermal Delivery Through in vivo Mouse Skin and Metabolic Path of Quantum Dots [J].
Tang Lei ;
Zhang Chun-Ling ;
Song Guang-Ming ;
Xu Zhong-Wei ;
Jin Xun .
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2012, 39 (02) :188-193
[15]   In vitro and in vivo transdermal delivery capacity of quantum dots through mouse skin [J].
Chu, Maoquan ;
Wu, Qiang ;
Wang, Jiaxu ;
Hou, Shengke ;
Miao, Yi ;
Peng, Jinliang ;
Sun, Ye .
NANOTECHNOLOGY, 2007, 18 (45)
[16]   Transdermal Macromolecular Delivery: Real-Time Visualisation of Iontophoretic and Chemically Enhanced Transport Using Two-Photon Excitation Microscopy [J].
Burrinder S. Grewal ;
Aarti Naik ;
William J. Irwin ;
Gert Gooris ;
Cees J. de Grauw ;
Hans G. Gerritsen ;
Joke A. Bouwstra .
Pharmaceutical Research, 2000, 17 :788-795
[17]   Transdermal macromolecular delivery: Real-time visualization of iontophoretic and chemically enhanced transport using two-photon excitation microscopy [J].
Grewal, BS ;
Naik, A ;
Irwin, WJ ;
Gooris, G ;
de Grauw, GJ ;
Gerritsen, HG ;
Bouwstra, JA .
PHARMACEUTICAL RESEARCH, 2000, 17 (07) :788-795
[18]   In Vivo Deep-Brain Structural and Hemodynamic Multiphoton Microscopy Enabled by Quantum Dots [J].
Liu, Hongji ;
Deng, Xiangquan ;
Tong, Shen ;
He, Chen ;
Cheng, Hui ;
Zhuang, Ziwei ;
Gan, Mengyao ;
Li, Jia ;
Xie, Weixin ;
Qiu, Ping ;
Wang, Ke .
NANO LETTERS, 2019, 19 (08) :5260-5265
[19]   Non endocytotic intracellular delivery of luminescent quantum dots mediated by a lytic peptide [J].
Mattoussi, Hedi ;
Safi, Malalk ;
Domitrovic, Tatiana ;
Zhan, Naiqian ;
Aldeek, Fadi ;
Johnson, John E. .
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247
[20]   Multiphoton luminescent graphene quantum dots for in vivo tracking of human adipose-derived stem cells [J].
Kim, Jin ;
Song, Sung Ho ;
Jin, Yoonhee ;
Park, Hyun-Ji ;
Yoon, Hyewon ;
Jeon, Seokwoo ;
Cho, Seung-Woo .
NANOSCALE, 2016, 8 (16) :8512-8519
12345