Rheumatoid vasculitis in a patient with seronegative rheumatoid arthritis

We report on a 47-year-old woman with a 10-year history of seronegative rheumatoid arthritis (RA) who had experienced an episode of bilateral aseptic pleuritis, and in whom livedo reticularis and ulcers had developed on both lower extremities, Histological examination revealed rheumatoid vasculitis. In rheumatoid vasculitis, high titers of rheumatoid factors are commonly observed. In our case, however, there have been no characteristic laboratory findings throughout the course of the disease so far, despite the active RA. This report describes a rare case of seronegative RA with systemic rheumatoid vasculitis.