Baimantuoluosides D-G, Four New Withanolide Glucosides from the Flower of Datura metel L.

被引：42
作者：
Yang, Bing-you
Xia, Yong-gang
Wang, Qiu-hong
Dou, De-qiang [2 ]
Kuang, Hai-xue [1 ]
机构：
[1] Heilongjiang Univ Chinese Med, Coll Pharm, Harbin 150040, Peoples R China
[2] Liaoning Univ Tradit Chinese Med, Dalian 116600, Peoples R China
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2010年 / 33卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Datura metel L; Solananceae; Withanolide glucosides; Baimantuoluosides; CONSTITUENTS;
D O I：
10.1007/s12272-010-0802-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In our search for bioactive anti-psoriasis compounds from the flower of Datura metel L, we isolated four new withanolide glucosides, baimantuoluosides D, E, F and G (1-4). The structures of the new compounds are (5 alpha,6 alpha,7 beta,22R)-5,6,7,27-tetrahydroxy-1-oxowitha-2,24-dien-27-O-beta-D-glucopyranoside (1), (5 alpha,6 beta,7 alpha,22R)-5,6,7,27-tetrahydroxy-1-oxowitha-2,24-dien-27-O-beta-D-glucopyranoside (2), (5 alpha,6 beta,7 alpha,12 beta,22R)-5,6,7,12,27-pentahydroxy-1-oxowitha-2,24-dien-27-O-beta-D-glucopyranoside (3), and (5 alpha,6 beta,22R)-5,6,27-trihydroxy-1-oxowitha-2,24-dien-27-O-beta-D-glucopyranoside (4) on the basis of chemical and physicochemical evidence.
引用
收藏
页码：1143 / 1148
页数：6
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