Enantioselective synthesis of 2-amino-4-(nitromethyl)-4H-chromene-3-carbonitriles from 2-iminochromenes

被引：9
作者：
Koz, Gamze [1 ]
Koz, Omer [1 ]
Coskun, Necdet [2 ]
机构：
[1] Bursa Tech Univ, Dept Chem, TR-16190 Bursa, Turkey
[2] Uludag Univ, Dept Chem, Bursa, Turkey
来源：
SYNTHETIC COMMUNICATIONS | 2016年 / 46卷 / 10期
关键词：
Amino alcohol catalyst; enantioselective conjugate addition; 2-iminochromene; nitromethane; ASYMMETRIC CONJUGATE ADDITION; MICHAEL ADDITION; PRIVILEGED STRUCTURES; EFFICIENT; DERIVATIVES; NITROALKANES; APOPTOSIS; CHROMENE; SALICYLALDEHYDES; MALONONITRILE;
D O I：
10.1080/00397911.2016.1177728
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of medicinally important 2-amino-4-(nitromethyl)-4H-chromene-3-carbonitriles were synthesized using enantioselective conjugate addition of nitromethane to 2-iminochromenes. The reactions were performed using L8-Cu (II) catalytic system and moderate to good enantioselectivities (62-88%) and yields (66-96%) were obtained.
引用
收藏
页码：909 / 915
页数：7
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