Serotonin Selectively Modulates Reward Value in Human Decision-Making

被引:170
|
作者
Seymour, Ben [1 ]
Daw, Nathaniel D. [2 ,3 ]
Roiser, Jonathan P. [4 ]
Dayan, Peter [3 ]
Dolan, Ray
机构
[1] UCL, Wellcome Trust Ctr Neuroimaging, Leopold Muller Funct Imaging Lab, London WC1N 3BG, England
[2] NYU, Dept Psychol, Ctr Neural Sci, New York, NY 10012 USA
[3] UCL, Gatsby Computat Neurosci Unit, London WC1N 3BG, England
[4] UCL, Inst Cognit Neurosci, London WC1N 3BG, England
来源
JOURNAL OF NEUROSCIENCE | 2012年 / 32卷 / 17期
基金
英国惠康基金;
关键词
ACUTE TRYPTOPHAN DEPLETION; PREFRONTAL CORTEX; ORBITOFRONTAL CORTEX; HEALTHY-VOLUNTEERS; DOPAMINE; NEURONS; PREDICTION; RECEPTORS; AVOIDANCE; BEHAVIOR;
D O I
10.1523/JNEUROSCI.0053-12.2012
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Establishing a function for the neuromodulator serotonin in human decision-making has proved remarkably difficult because if its complex role in reward and punishment processing. In a novel choice task where actions led concurrently and independently to the stochastic delivery of both money and pain, we studied the impact of decreased brain serotonin induced by acute dietary tryptophan depletion. Depletion selectively impaired both behavioral and neural representations of reward outcome value, and hence the effective exchange rate by which rewards and punishments were compared. This effect was computationally and anatomically distinct from a separate effect on increasing outcome-independent choice perseveration. Our results provide evidence for a surprising role for serotonin in reward processing, while illustrating its complex and multifarious effects.
引用
收藏
页码:5833 / 5842
页数:10
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