Serotonin Selectively Modulates Reward Value in Human Decision-Making

被引:170
|
作者
Seymour, Ben [1 ]
Daw, Nathaniel D. [2 ,3 ]
Roiser, Jonathan P. [4 ]
Dayan, Peter [3 ]
Dolan, Ray
机构
[1] UCL, Wellcome Trust Ctr Neuroimaging, Leopold Muller Funct Imaging Lab, London WC1N 3BG, England
[2] NYU, Dept Psychol, Ctr Neural Sci, New York, NY 10012 USA
[3] UCL, Gatsby Computat Neurosci Unit, London WC1N 3BG, England
[4] UCL, Inst Cognit Neurosci, London WC1N 3BG, England
来源
JOURNAL OF NEUROSCIENCE | 2012年 / 32卷 / 17期
基金
英国惠康基金;
关键词
ACUTE TRYPTOPHAN DEPLETION; PREFRONTAL CORTEX; ORBITOFRONTAL CORTEX; HEALTHY-VOLUNTEERS; DOPAMINE; NEURONS; PREDICTION; RECEPTORS; AVOIDANCE; BEHAVIOR;
D O I
10.1523/JNEUROSCI.0053-12.2012
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Establishing a function for the neuromodulator serotonin in human decision-making has proved remarkably difficult because if its complex role in reward and punishment processing. In a novel choice task where actions led concurrently and independently to the stochastic delivery of both money and pain, we studied the impact of decreased brain serotonin induced by acute dietary tryptophan depletion. Depletion selectively impaired both behavioral and neural representations of reward outcome value, and hence the effective exchange rate by which rewards and punishments were compared. This effect was computationally and anatomically distinct from a separate effect on increasing outcome-independent choice perseveration. Our results provide evidence for a surprising role for serotonin in reward processing, while illustrating its complex and multifarious effects.
引用
收藏
页码:5833 / 5842
页数:10
相关论文
共 50 条
  • [21] Adolescent risky decision-making: Neurocognitive development of reward and control regions
    Van Leijenhorst, Linda
    Moor, Bregtje Gunther
    de Macks, Zdena A. Op
    Rombouts, Serge A. R. B.
    Westenberg, P. Michiel
    Crone, Eveline A.
    NEUROIMAGE, 2010, 51 (01) : 345 - 355
  • [22] Reward-driven changes in striatal pathway competition shape evidence evaluation in decision-making
    Dunovan, Kyle
    Vich, Catalina
    Clapp, Matthew
    Verstynen, Timothy
    Rubin, Jonathan
    PLOS COMPUTATIONAL BIOLOGY, 2019, 15 (05)
  • [23] Goal congruency dominates reward value in accounting for behavioral and neural correlates of value-based decision-making
    Fromer, Romy
    Wolf, Carolyn K. Dean
    Shenhav, Amitai
    NATURE COMMUNICATIONS, 2019, 10 (1)
  • [24] Reward-driven decision-making impairments in schizophrenia
    Saperia, Sarah
    Da Silva, Susana
    Siddiqui, Ishraq
    Agid, Ofer
    Daskalakis, Z. Jeff
    Ravindran, Arun
    Voineskos, Aristotle N.
    Zakzanis, Konstantine K.
    Remington, Gary
    Foussias, George
    SCHIZOPHRENIA RESEARCH, 2019, 206 : 277 - 283
  • [25] Effects of Emotional Preferences on Value-based Decision-making Are Mediated by Mentalizing and Reward Networks
    Evans, Simon
    Fleming, Stephen M.
    Dolan, Raymond J.
    Averbeck, Bruno B.
    JOURNAL OF COGNITIVE NEUROSCIENCE, 2011, 23 (09) : 2197 - 2210
  • [26] The value of foresight: how prospection affects decision-making
    Pezzulo, Giovanni
    Rigoli, Francesco
    FRONTIERS IN NEUROSCIENCE, 2011, 5
  • [27] Structure Learning in Human Sequential Decision-Making
    Acuna, Daniel E.
    Schrater, Paul
    PLOS COMPUTATIONAL BIOLOGY, 2010, 6 (12)
  • [28] Metacontrol of decision-making strategies in human aging
    Bolenz, Florian
    Kool, Wouter
    Reiter, Andrea M. F.
    Eppinger, Ben
    ELIFE, 2019, 8
  • [29] The human amygdala encodes value and space during decision making
    Ousdal, Olga Therese
    Specht, Karsten
    Server, Andres
    Andreassen, Ole A.
    Dolan, Ray J.
    Jensen, Jimmy
    NEUROIMAGE, 2014, 101 : 712 - 719
  • [30] Biologically plausible mechanisms underlying motor response correction during reward-based decision-making
    Lee, Jung Hoon
    NEUROCOMPUTING, 2020, 412 : 416 - 425