Serotonin Selectively Modulates Reward Value in Human Decision-Making

被引:170
|
作者
Seymour, Ben [1 ]
Daw, Nathaniel D. [2 ,3 ]
Roiser, Jonathan P. [4 ]
Dayan, Peter [3 ]
Dolan, Ray
机构
[1] UCL, Wellcome Trust Ctr Neuroimaging, Leopold Muller Funct Imaging Lab, London WC1N 3BG, England
[2] NYU, Dept Psychol, Ctr Neural Sci, New York, NY 10012 USA
[3] UCL, Gatsby Computat Neurosci Unit, London WC1N 3BG, England
[4] UCL, Inst Cognit Neurosci, London WC1N 3BG, England
来源
JOURNAL OF NEUROSCIENCE | 2012年 / 32卷 / 17期
基金
英国惠康基金;
关键词
ACUTE TRYPTOPHAN DEPLETION; PREFRONTAL CORTEX; ORBITOFRONTAL CORTEX; HEALTHY-VOLUNTEERS; DOPAMINE; NEURONS; PREDICTION; RECEPTORS; AVOIDANCE; BEHAVIOR;
D O I
10.1523/JNEUROSCI.0053-12.2012
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Establishing a function for the neuromodulator serotonin in human decision-making has proved remarkably difficult because if its complex role in reward and punishment processing. In a novel choice task where actions led concurrently and independently to the stochastic delivery of both money and pain, we studied the impact of decreased brain serotonin induced by acute dietary tryptophan depletion. Depletion selectively impaired both behavioral and neural representations of reward outcome value, and hence the effective exchange rate by which rewards and punishments were compared. This effect was computationally and anatomically distinct from a separate effect on increasing outcome-independent choice perseveration. Our results provide evidence for a surprising role for serotonin in reward processing, while illustrating its complex and multifarious effects.
引用
收藏
页码:5833 / 5842
页数:10
相关论文
共 50 条
  • [1] Serotonin transporter dosage modulates long-term decision-making in rat and human
    Homberg, Judith R.
    van den Bos, Ruud
    den Heijer, Esther
    Suer, Remco
    Cuppen, Edwin
    NEUROPHARMACOLOGY, 2008, 55 (01) : 80 - 84
  • [2] The human subthalamic nucleus encodes the subjective value of reward and the cost of effort during decision-making
    Zenon, Alexandre
    Duclos, Yann
    Carron, Romain
    Witjas, Tatiana
    Baunez, Christelle
    Regis, Jean
    Azulay, Jean-Philippe
    Brown, Peter
    Eusebio, Alexandre
    BRAIN, 2016, 139 : 1830 - 1843
  • [3] Dopamine Modulates Dynamic Decision-Making during Foraging
    Le Heron, Campbell
    Kolling, Nils
    Plant, Olivia
    Kienast, Annika
    Janska, Rebecca
    Ang, Yuen-Siang
    Fallon, Sean
    Husain, Masud
    Apps, Matthew A. J.
    JOURNAL OF NEUROSCIENCE, 2020, 40 (27): : 5273 - 5282
  • [4] Emotion and reasoning in human decision-making
    Rolls, Edmund T.
    ECONOMICS-THE OPEN ACCESS OPEN-ASSESSMENT E-JOURNAL, 2019, 13
  • [5] Compromised decision-making and increased gambling proneness following dietary serotonin depletion in rats
    Koot, S.
    Zoratto, F.
    Cassano, T.
    Colangeli, R.
    Laviola, G.
    van den Bos, R.
    Adriani, W.
    NEUROPHARMACOLOGY, 2012, 62 (04) : 1640 - 1650
  • [6] Serotonin modulates asymmetric learning from reward and punishment in healthy human volunteers
    Michely, Jochen
    Eldar, Eran
    Erdman, Alon
    Martin, Ingrid M.
    Dolan, Raymond J.
    COMMUNICATIONS BIOLOGY, 2022, 5 (01)
  • [7] Impulsivity and rapid decision-making for reward
    Heyes, Stephanie Burnett
    Adam, Robert J.
    Urner, Maren
    van der Leer, Leslie
    Bahrami, Bahador
    Bays, Paul M.
    Husain, Masud
    FRONTIERS IN PSYCHOLOGY, 2012, 3
  • [8] Decision-Making, Sensitivity to Reward and Attrition in Weight Management
    Koritzky, Gilly
    Dieterle, Camille
    Rice, Chantelle
    Jordan, Katie
    Bechara, Antoine
    OBESITY, 2014, 22 (08) : 1904 - 1909
  • [9] Influence of Dopaminergically Mediated Reward on Somatosensory Decision-Making
    Pleger, Burkhard
    Ruff, Christian C.
    Blankenburg, Felix
    Kloeppel, Stefan
    Driver, Jon
    Dolan, Raymond J.
    PLOS BIOLOGY, 2009, 7 (07):
  • [10] Fidelity of the representation of value in decision-making
    Bays, Paul M.
    Dowding, Ben A.
    PLOS COMPUTATIONAL BIOLOGY, 2017, 13 (03)