Recent Advances in Microbial Synthesis of Poly-γ-Glutamic Acid: A Review

被引：29
作者：
Li, Danfeng [1 ]
Hou, Lizhen [1 ]
Gao, Yaxin [1 ]
Tian, Zhiliang [1 ]
Fan, Bei [1 ,2 ]
Wang, Fengzhong [2 ,3 ]
Li, Shuying [1 ]
机构：
[1] Chinese Acad Agr Sci, Inst Food Sci & Technol, 2 Yuan Ming Yuan West Rd, Beijing 100193, Peoples R China
[2] Chinese Acad Agr Sci, Minist Agr & Rural Affairs, Key Lab Agroprod Qual & Safety Control Storage &, Beijing 100193, Peoples R China
[3] Chinese Acad Agr Sci, Minist Agr & Rural Affairs, Key Lab Agroprod Proc, Beijing 100193, Peoples R China
来源：
FOODS | 2022年 / 11卷 / 05期
关键词：
poly-gamma-glutamic acid; Bacillus species; microbial synthesis; metabolic pathway; industrial application; BACILLUS-SUBTILIS NATTO; DRUG-DELIVERY SYSTEM; POLY(GAMMA-GLUTAMIC ACID); POLYGLUTAMIC ACID; MOLECULAR-WEIGHT; POLY-(GAMMA-GLUTAMIC ACID); FERMENTATIVE PRODUCTION; INDEPENDENT PRODUCTION; ECONOMICAL PRODUCTION; ENHANCED PRODUCTION;
D O I：
10.3390/foods11050739
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Poly-gamma-glutamic acid (gamma-PGA) is a natural, safe, non-immunogenic, biodegradable, and environmentally friendly glutamic biopolymer. gamma-PGA has been regarded as a promising bio-based materials in the food field, medical field, even in environmental engineering field, and other industrial fields. Microbial synthesis is an economical and effective way to synthesize gamma-PGA. Bacillus species are the most widely studied producing strains. gamma-PGA biosynthesis involves metabolic pathway of racemization, polymerization, transfer, and catabolism. Although microbial synthesis of gamma-PGA has already been used extensively, productivity and yield remain the major constraints for its industrial application. Metabolic regulation is an attempt to solve the above bottleneck problems and meet the demands of commercialization. Therefore, it is important to understand critical factors that influence gamma-PGA microbial synthesis in depth. This review focuses on production strains, biosynthetic pathway, and metabolic regulation. Moreover, it systematically summarizes the functional properties, purification procedure, and industrial application of gamma-PGA.
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页数：19
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