Sclerostin and chronic kidney disease

被引：1
作者：
Mierzwinska, Emilia [1 ]
Hryszko, Tomasz [1 ]
Szablak-Uliszewska, Emilia [1 ]
Naumnik, Beata [1 ]
机构：
[1] Uniwersytet Med Bialymstoku, Osrodkiem Dializ, Klin Nefrol & Transplantol 1, Ul Zurawia 14, PL-15540 Bialystok, Poland
来源：
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ | 2017年 / 71卷
关键词：
Wnt/beta-catenin signaling pathway; sclerostin; chronic kidney disease; bone and mineral disorders in chronic kidney disease; vascular calcification; BONE-MINERAL DENSITY; SERUM SCLEROSTIN; VASCULAR CALCIFICATION; CIRCULATING SCLEROSTIN; CARDIOVASCULAR EVENTS; RENAL OSTEODYSTROPHY; PARATHYROID-HORMONE; MECHANICAL STRAIN; DIALYSIS PATIENTS; EXPRESSION;
D O I：
10.5604/01.3001.0010.7605
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Chronic kidney disease (CKD) leads to the development of mineral and skeletal disturbances. They increase the risk of fractures, cardiovascular complications and, in consequence, decrease patients' lifespan. Wnt/beta-catenin pathway plays an important role in the development and homeostasis of the skeleton. The system is tightly regulated by group of inhibitors, such as sclerostin. Sclerostin inhibits bone formation and increases its resorption. There is mounting evidence that sclerostin may take part in the progress of bone and cardiovascular complications among patients with CKD. This review presents the current state of knowledge on the role of sclerostin in bone and cardiovascular disturbances in CKD patients.
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收藏
页码：1198 / 1206
页数：9
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