Does Lipid Emulsion Reduce Amphotericin B Nephrotoxicity? A Systematic Review and Meta-analysis

被引：69

作者：

Mistro, Sostenes ^{[1
]}

Maciel, Isis de M. ^{[1
]}

de Menezes, Rouseli G. ^{[1
]}

Maia, Zuinara P. ^{[1
]}

Schooley, Robert T. ^{[2
]}

Badaro, Roberto ^{[1
,2
]}

机构：

[1] Univ Fed Bahia, Univ Hosp Prof Edgard Santos, Salvador, BA, Brazil

[2] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2012年 / 54卷 / 12期

关键词：

FAT EMULSION; TOXICITY;

D O I：

10.1093/cid/cis290

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This meta-analysis of 13 studies revealed that amphotericin B delivered as a locally prepared lipid emulsion or in liposomes reduced nephrotoxicity to a similar degree, by 18.4% (relative risk [RR], 0.40 [99% confidence interval,.25-.64]; n = 459) and 18.1% (RR, 0.48 [99% CI,.36-. 64]); n = 1233), respectively.

引用

页码：1774 / 1777

页数：4

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