MicroRNAs at the Host-Bacteria Interface: Host Defense or Bacterial Offense

被引：85

作者：

Aguilar, Carmen ^{[1
]}

Mano, Miguel ^{[2
]}

Eulalio, Ana ^{[1
,3
]}

机构：

[1] Univ Wurzburg, IMIB, Host RNA Metab Grp, Wurzburg, Germany

[2] Univ Coimbra, Funct Genom & RNA Based Therapeut Grp, Ctr Neurosci & Cell Biol CNC, Coimbra, Portugal

[3] Univ Coimbra, RNA & Infect Grp, Ctr Neurosci & Cell Biol CNC, Coimbra, Portugal

来源：

TRENDS IN MICROBIOLOGY | 2019年 / 27卷 / 03期

关键词：

HELICOBACTER-PYLORI INFECTION; INDUCED GASTRIC CARCINOGENESIS; MYCOBACTERIUM-TUBERCULOSIS; ANTIMICROBIAL RESPONSES; INTRACELLULAR SURVIVAL; CELL-PROLIFERATION; IMMUNE-RESPONSE; CANCER; AUTOPHAGY; EXPRESSION;

D O I：

10.1016/j.tim.2018.10.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs are a class of small noncoding RNAs that act as major post-transcriptional regulators of gene expression. They are currently recognized for their important role in the intricate interaction between host and bacterial pathogens, either as part of the host immune response to neutralize infection, or as a molecular strategy employed by bacteria to hijack host pathways for their own benefit. Here, we summarize recent advances on the function of miRNAs during infection of mammalian hosts by bacterial pathogens, highlighting key cellular pathways. In addition, we discuss emerging themes in this field, including the participation of miRNAs in host-microbiota crosstalk and cell-to-cell communication.

引用

页码：206 / 218

页数：13

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