Tumor activated platelets induce vascular mimicry in mesenchymal stem cells and aid metastasis

被引：7

作者：

Bhuniya, Avishek ^{[1
]}

Sarkar, Anirban ^{[1
]}

Guha, Aishwarya ^{[1
]}

Choudhury, Pritha Roy ^{[1
]}

Bera, Saurav ^{[1
]}

Sultana, Jasmine ^{[1
]}

Chakravarti, Mohona ^{[1
]}

Dhar, Sukanya ^{[1
]}

Das, Juhina ^{[1
]}

Guha, Ipsita ^{[1
]}

Ganguly, Nilanjan ^{[1
]}

Banerjee, Saptak ^{[1
]}

Bose, Anamika ^{[1
]}

Baral, Rathindranath ^{[1
]}

机构：

[1] Chittaranjan Natl Canc Inst, Dept Immunoregulat & Immunodiagnost, 37 SP Mukherjee Rd, Kolkata 700026, India

来源：

CYTOKINE | 2022年 / 158卷

关键词：

Mesenchymal-stem-cells; Platelets; Vascular; -mimicry; Metastasis; E-cadherin; Vimentin; ANGIOGENESIS;

D O I：

10.1016/j.cyto.2022.155998

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Extent of metastasis influences activation of platelets in tumor-microenvironment. Activated platelets potentiate mesenchymal-stem-cells (MSCs) to migrate in secondary metastatic sites without participation in process of invasion. Presence of higher percentage of MSCs along with activated-platelets induces formation of vascular -mimicry (VM). The pathophysiology, VM, has already been reported in multiple types of cancer including lung, ovary, melanoma etc. and related to poor-prognosis. Interaction of MSCs with platelets in cell-to-cell contact dependent manner is essential for their migration, thereby, VM. Evidences are obtained suggesting that under influence of tumor-associated-activated-platelets, expressions of vimentin, ve-cadherin are increased, along with decrease in e-cadherin on CD105+ MSCs in both mRNA and protein levels that may help in formation of vessel like structure in VM. Adoptive transfer of MSCs along with tumor-activated-platelets causes greater B16 melanoma metastasis at lungs in comparison to MSCs with non-activated platelets. Presence of CD105+Vimentin+ MSCs in vessel like structure in the metastatic lung confirms the involvement of platelet-activated-MSCs in VM, thereby, in metastasis.

引用

页数：10

共 31 条

[1] Vascular Mimicry: A Novel Neovascularization Mechanism Driving Anti-Angiogenic Therapy (AAT) Resistance in Glioblastoma [J].