The expanding field of IgG4-mediated neurological autoimmune disorders

被引：142

作者：

Huijbers, M. G. ^{[1
,2
]}

Querol, L. A. ^{[3
]}

Niks, E. H. ^{[1
]}

Plomp, J. J. ^{[1
]}

van der Maarel, S. M. ^{[2
]}

Graus, F. ^{[3
]}

Dalmau, J. ^{[3
]}

Illa, I. ^{[3
]}

Verschuuren, J. J. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Neurol, NL-2300 RC Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Human Genet, NL-2300 RC Leiden, Netherlands

[3] Hosp Santa Creu & Sant Pau, Dept Neurol, Barcelona, Spain

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2015年 / 22卷 / 08期

关键词：

autoimmunity; CIDP; IgG4; Iglon5; Lgi1; membranous nephropathy; MuSK myasthenia gravis; neurofascin; pemphigus; MUSCLE-SPECIFIC KINASE; THROMBOTIC THROMBOCYTOPENIC PURPURA; INFLAMMATORY DEMYELINATING POLYNEUROPATHY; IDIOPATHIC MEMBRANOUS NEPHROPATHY; SERONEGATIVE MYASTHENIA-GRAVIS; ANTIBODY-POSITIVE MG; FAB-ARM EXCHANGE; PEMPHIGUS-VULGARIS; IGG4; AUTOANTIBODIES; MUSK ANTIBODIES;

D O I：

10.1111/ene.12758

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

At least 13 different disease entities affecting the central nervous system, peripheral nervous system and connective tissue of the skin or kidneys are associated with immunoglobulin G4 (IgG4) immune reactivity. IgG4 has always been considered a benign, non-inflammatory subclass of IgG, in contrast to the well-known complement-activating pro-inflammatory IgG1 subclass. A comprehensive review of these IgG4 autoimmune disorders reveals striking similarities in epitope binding and human leukocyte antigen (HLA) associations. Mechanical interference of extracellular ligand-receptor interactions by the associated IgG4 antibodies seems to be the common/converging disease mechanism in these disorders.

引用

页码：1151 / 1161

页数：11

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