Structural and functional studies of erythrocyte membrane-skeleton by single-cell and single-molecule techniques

被引：6

作者：

Xing, Fulin ^{[1
,2
]}

Hu, Fen ^{[1
,2
]}

Yang, Jianyu ^{[1
,2
]}

Pan, Leiting ^{[1
,2
]}

Xu, Jingjun ^{[1
,2
,3
]}

机构：

[1] Nankai Univ, Minist Educ, Sch Phys, Key Lab Weak Light Nonlinear Photon, Tianjin 300071, Peoples R China

[2] Nankai Univ, Inst Appl Phys, TEDA, Tianjin 300071, Peoples R China

[3] Shanxi Univ, Collaborat Innovat Ctr Extreme Opt, Taiyuan 030006, Shanxi, Peoples R China

来源：

JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES | 2019年 / 12卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Red blood cells; membrane-skeleton; optical tweezers; microfluidics; super-resolution microscopy; RED-BLOOD-CELL; ATOMIC-FORCE MICROSCOPY; TYPE-2; DIABETES-MELLITUS; OPTICAL TWEEZERS; PATHOLOGICAL ERYTHROCYTES; TEMPERATURE-DEPENDENCE; NATIVE ULTRASTRUCTURE; MICROFLUIDIC ANALYSIS; MECHANICAL-PROPERTIES; DEFORMABILITY;

D O I：

10.1142/S1793545818300045

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

As the indispensable oxygen-transporting cells, erythrocytes exhibit extreme deformability and amazing stability as they are subject to huge reversible shear stress and extrusion force during massive circulation in the body. The unique architecture of spectrin-actin-based membrane-skeleton is considered to be responsible for such excellent mechanical properties of erythrocytes. Although erythrocytes have been recognized for more than 300 years, myriad questions about membrane-skeleton constantly attract people's attention. Here, we summarize the kinds of distinctive single-cell and single-molecule techniques that were used to investigate the structure and function of erythrocyte membrane-skeleton at macro and micro levels.

引用

页数：13

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