Urea mediated 5-substituted-1H-tetrazole via [3+2] cycloaddition of nitriles and sodium azide

被引：15
|
作者：
Yakambram, B. [1 ,2 ]
Shree, A. Jaya [2 ]
Reddy, L. Srinivasula [1 ]
Satyanarayana, T. [1 ]
Naveen, P. [2 ]
Bandichhor, Rakeshwar [1 ]
机构：
[1] Dr Reddys Labs Ltd, Integrated Prod Dev, Innovat Plaza, Qutubullapur 500090, Telangana, India
[2] Jawaharlal Nehru Technol Univ Hyderabad, Ctr Chem Sci & Technol, IST, Kukatpally 500085, Telangana, India
来源：
TETRAHEDRON LETTERS | 2018年 / 59卷 / 05期
关键词：
Urea; Cycloaddition; Tetrazole; Azide; CATALYZED SYNTHESIS; HETEROGENEOUS CATALYST; TRIMETHYLSILYL AZIDE; TETRAZOLE FORMATION; EFFICIENT SYNTHESIS; 1H-TETRAZOLES; CHEMISTRY;
D O I：
10.1016/j.tetlet.2017.12.067
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, new and convenient metal free procedure for the synthesis of 5-substituted 1H-tetrazoles using various nitriles and sodium azide in the presence of urea and acetic acid with good to high yields is developed. The reaction plausibly proceeds through in situ formation of urea azide active complex without toxic and/or expensive metal catalysts. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：445 / 449
页数：5
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